You ask some really great questions. I refused to take SSRIs when I was severely depressed because I researched them extensively, and discovered that there was great concern for long-term sexual dysfunction. I realized there was no point in being happy if my **** didn't work (not like they'd magically make me happy anyway), and that I'd probably be even more depressed if my sex drive worsened. I am far from an expert on the subject, but I have read that SSRIs can dysregulate dopaminergic neurotransmission, and that cabergoline has occasionally been concomitantly prescribed to combat these effects. If your worsened sex drive has anything to do with dopamine, there is a very good chance, hypothetically, that a low dose of cabergoline might result in improvement. Of course, do so at your own discretion and under the supervision of your doctor. If your doc refuses, you can always purchase it on alldaychemist.
Assuming you are using the sensitive E2 test (I'd hope), your e2 levels are probably too high for someone with low SHBG. Remember that like testosterone, estradiol is a sex hormone, and therefore bound by SHBG. The issue with estradiol and low SHBG (as Dr Crisler has explained) is that because androgens (especially DHT, the most important hormone for male sex drive) bind with higher affinity to SHBG than estrogens, they are quickly flushed from the system while the latter group tends to accumulate with disproportionately high levels of free hormone. Assuming you are using the sensitive E2 test, you'd probably be better off with total levels between 20-35 pg/mL.
