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Fasedienol (PH94B) Nasal Spray is a safe fast-acting and odourless neuroactive steroid

[URL unfurl="true"]https://www.vistagen.com/pipeline/PH94B/overview[/URL]

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Fasedienol (PH94B) Nasal Spray for Social Anxiety Disorder
Vistagen’s fasedienol (PH94B) is a first-in-class, rapid-onset investigational neuroactive pherine nasal spray in Phase 3 clinical development for acute treatment of anxiety in adults with social anxiety disorder (SAD). Designed for intranasal administration in low microgram doses, the proposed novel mechanism of action (MOA) of fasedienol is fundamentally differentiated from all current anti-anxiety medications, including all antidepressants approved by the U.S. Food and Drug Administration (FDA) for the treatment of SAD, as well as all benzodiazepines and beta blockers prescribed for SAD on an off-label basis.

When administered intranasally, fasedienol activates receptors of peripheral nasal chemosensory neurons connected to subsets of neurons in the olfactory bulbs that, in turn, connect to neurons in the limbic amygdala involved in the pathophysiology of SAD and potentially other anxiety and mood disorders. Fasedienol is pharmacologically active without requiring apparent systemic absorption and distribution of the compound to the brain to achieve its rapid-onset and short duration of anxiolytic effects.

[URL unfurl="true"]https://www.vistagen.com/news/videos[/URL]

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<blockquote data-quote="madman" data-source="post: 277910" data-attributes="member: 13851">Fasedienol (PH94B) Nasal Spray is a safe fast-acting and odourless neuroactive steroid[URL unfurl=&quot;true&quot;]https://www.vistagen.com/pipeline/PH94B/overview[/URL][ATTACH=full]42574[/ATTACH]<h2>Fasedienol (PH94B) Nasal Spray for Social Anxiety Disorder</h2>Vistagen’s fasedienol (PH94B) is a first-in-class, rapid-onset investigational neuroactive pherine nasal spray in Phase 3 clinical development for acute treatment of anxiety in adults with social anxiety disorder (SAD). Designed for intranasal administration in low microgram doses, the proposed novel mechanism of action (MOA) of fasedienol is fundamentally differentiated from all current anti-anxiety medications, including all antidepressants approved by the U.S. Food and Drug Administration (FDA) for the treatment of SAD, as well as all benzodiazepines and beta blockers prescribed for SAD on an off-label basis.When administered intranasally, fasedienol activates receptors of peripheral nasal chemosensory neurons connected to subsets of neurons in the olfactory bulbs that, in turn, connect to neurons in the limbic amygdala involved in the pathophysiology of SAD and potentially other anxiety and mood disorders. Fasedienol is pharmacologically active without requiring apparent systemic absorption and distribution of the compound to the brain to achieve its rapid-onset and short duration of anxiolytic effects.[URL unfurl=&quot;true&quot;]https://www.vistagen.com/news/videos[/URL][ATTACH=full]42570[/ATTACH][ATTACH=full]42571[/ATTACH][ATTACH=full]42572[/ATTACH][ATTACH=full]42573[/ATTACH]</blockquote>

[QUOTE="madman, post: 277910, member: 13851"] [B]Fasedienol (PH94B) Nasal Spray is a safe fast-acting and odourless neuroactive steroid[/B] [URL unfurl="true"]https://www.vistagen.com/pipeline/PH94B/overview[/URL] [B][ATTACH type="full" alt="1711377983388.png"]42574[/ATTACH][/B] [HEADING=1]Fasedienol (PH94B) Nasal Spray for Social Anxiety Disorder[/HEADING] [I][B]Vistagen’s fasedienol (PH94B) is a first-in-class, rapid-onset investigational neuroactive pherine nasal spray in Phase 3 clinical development for acute treatment of anxiety in adults with social anxiety disorder (SAD).[/B] Designed for intranasal administration in low microgram doses, the proposed novel mechanism of action (MOA) of fasedienol is fundamentally differentiated from all current anti-anxiety medications, including all antidepressants approved by the U.S. Food and Drug Administration (FDA) for the treatment of SAD, as well as all benzodiazepines and beta blockers prescribed for SAD on an off-label basis. [B]When administered intranasally, fasedienol activates receptors of peripheral nasal chemosensory neurons connected to subsets of neurons in the olfactory bulbs that, in turn, connect to neurons in the limbic amygdala involved in the pathophysiology of SAD and potentially other anxiety and mood disorders. Fasedienol is pharmacologically active without requiring apparent systemic absorption and distribution of the compound to the brain to achieve its rapid-onset and short duration of anxiolytic effects.[/B][/I] [URL unfurl="true"]https://www.vistagen.com/news/videos[/URL] [B][ATTACH type="full" alt="Screenshot (33855).png"]42570[/ATTACH] [ATTACH type="full" alt="Screenshot (33856).png"]42571[/ATTACH] [ATTACH type="full" alt="Screenshot (33857).png"]42572[/ATTACH] [ATTACH type="full" alt="Screenshot (33859).png"]42573[/ATTACH][/B] [/QUOTE]

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TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038