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Haven't really done much supplementation since I took this. My diet is very clean, lots of vegetables, fish chicken, very little sugar. Only supplements I take our vitamin D and fish oil. I do notice that there is response, less joint pain. But I don't want to go back to weightlifting as I have had a lot, and I mean a lot, orthopedic problems knee surgery, hip replacement, and I am currently holding out on getting my other hip replaced which I know will need to be done at some point in the next two years. The battle goes on!