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For some reason it seems to interfere with HCG rather drastically in my case. I couldn't figure out why all of the sudden I felt like I was crashing my levels after having just started *** oil for sleep and pain. Apparently there are studies that show that leydig cells have receptors for cannabinoids and they can suppress testosterone production. So for someone on TRT, probably not an issue, but for someone on HCG monotherapy, potentially a big issue.

[QUOTE="Greyfox, post: 143026, member: 26136"] For some reason it seems to interfere with HCG rather drastically in my case. I couldn't figure out why all of the sudden I felt like I was crashing my levels after having just started *** oil for sleep and pain. Apparently there are studies that show that leydig cells have receptors for cannabinoids and they can suppress testosterone production. So for someone on TRT, probably not an issue, but for someone on HCG monotherapy, potentially a big issue. [/QUOTE]

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TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038