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I will say that I had switched to natesto last year for a couple months and it inadvertently ended up being somewhat of a hpta restart as I had a knee surgery and got a awful cold after, in which I couldn’t administer the natesto for over a week, and decided to try a restart. On and off shots and cream for a few years and it felt like the restart was far easier than a typical clomid/hcg restart. For those wanting to do a restart but hesitant would be worth a look at doing the natesto for a couple months then proceeding with the restart to lessen the impact possibly.