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Data point for anyone interested. Natesto has been the most tolerable form of TRT for me. Typically, I get headaches with other forms. I have also noticed a more forceful heartbeat than normal after injecting. I can even feel it in my abdominal aorta (I know, that sounds really weird).


I have been following my blood pressure more closely lately and have noticed a general increase while on injections. I started to wonder if the headaches and blood pressure are related (ie, does one cause the other, or does a common process cause both?).


I happen to be on a calcium channel blocker for migraine prevention. Have been for a while. I decided it would be a good idea to try a beta blocker for a few reasons. Beta blockers are first line migraine prevention drugs (check, good for me). And, I am starting to believe that Test has beta adrenergic activity that varies among individuals. Maybe I am more sensitive than others? If so, a beta blocker would blunt the effect.


Started propanol the other day. I have noticed a definite improvement in the "forceful" hearbeat phenomenon described above. I think I am also tolerating injections better - less headache. That said, I still sense a very minor, dull headache. It may not be related to the injection and I would have to observe for a longer period of time to make conclusions. On the other hand, although I still experience a very mild headache, I think I may have confirmed my theory that my headaches are in some way related to beta agonism and/or blood pressure.


Despite all this, I am once again thinking about going back to Natesto. I swing back and forth because while on injections or cream, I long for not getting headaches.  I am still a huge proponent of Natesto, but while on it, I wonder if I am under treated a bit? I don't always feel this way. At times, I notice a significant boost in mood. I would even say libido is probably better on it.


So, I wanted to provide some input and check with others in this thread. Am I still the only one here interested in Natesto? I'd love for some more guys to give it a longer run so we can compare notes.


I would also encourage everyone to follow their blood pressure. It's a good idea in general, but I think it would be useful to see how common BP spikes are after injection. I bought an Omron and really like it. My wife and I both use it and can track our pressure separately by syncing to an app. I may even start a new thread to encourage guys to track BP.


TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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