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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Obesity and male hypogonadism: Tales of a vicious cycle
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<blockquote data-quote="madman" data-source="post: 147292" data-attributes="member: 13851"><p>[ATTACH=full]7385[/ATTACH]</p><p><strong><span style="color: rgb(184, 49, 47)">FIGURE 1</span></strong> <strong>Schematic illustration of the hypothesized vicious cycle between male hypogonadism and obesity</strong>. Fat accumulation in the adipose tissue increases leptin synthesis and secretion. High circulating leptin levels ultimately lead to leptin resistance due to saturation of leptin transport into the central nervous system and decreased expression of leptin receptors. Decreased leptin response will then be responsible not only for reduced satiety, increased food intake, and energy accumulation but also for the disruption of the hypothalamic‐pituitary‐testes axis, resulting in decreased testosterone production. While testosterone antagonizes lipid accumulation in the adipose tissue, low testosterone levels in hypogonadal men result in the lost of this inhibitory signal, which then results in further fat accumulation. Simultaneously, an increased aromatase expression in the adipose tissue leads to an increased aromatization of testosterone into estradiol, which triggers a negative feedback mechanism on the hypothalamus. However, this classical role of estradiol in the obesity‐hypogonadism cycle (represented by dotted lines) has been recently challenged [Colour figure can be viewed at wileyonlinelibrary.com]</p></blockquote><p></p>
[QUOTE="madman, post: 147292, member: 13851"] [ATTACH=full]7385[/ATTACH] [B][COLOR=rgb(184, 49, 47)]FIGURE 1[/COLOR][/B] [B]Schematic illustration of the hypothesized vicious cycle between male hypogonadism and obesity[/B]. Fat accumulation in the adipose tissue increases leptin synthesis and secretion. High circulating leptin levels ultimately lead to leptin resistance due to saturation of leptin transport into the central nervous system and decreased expression of leptin receptors. Decreased leptin response will then be responsible not only for reduced satiety, increased food intake, and energy accumulation but also for the disruption of the hypothalamic‐pituitary‐testes axis, resulting in decreased testosterone production. While testosterone antagonizes lipid accumulation in the adipose tissue, low testosterone levels in hypogonadal men result in the lost of this inhibitory signal, which then results in further fat accumulation. Simultaneously, an increased aromatase expression in the adipose tissue leads to an increased aromatization of testosterone into estradiol, which triggers a negative feedback mechanism on the hypothalamus. However, this classical role of estradiol in the obesity‐hypogonadism cycle (represented by dotted lines) has been recently challenged [Colour figure can be viewed at wileyonlinelibrary.com] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Obesity and male hypogonadism: Tales of a vicious cycle
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