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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Obesity and male hypogonadism: Tales of a vicious cycle
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<blockquote data-quote="madman" data-source="post: 147291" data-attributes="member: 13851"><p><strong><span style="color: rgb(184, 49, 47)">Summary</span></strong></p><p>Obesity prevalence, particularly in children and young adults, is perilously increasing worldwide foreseeing serious negative health impacts in the future to come. Obesity is linked to impaired male gonadal function and is currently a major cause of hypogonadism. Besides signs and symptoms directly derived from decreased circulating testosterone levels, males with obesity also present poor fertility outcomes, further evidencing the parallelism between obesity and male reproductive function. In addition, males with androgen deficiency also exhibit increased fat accumulation and reduced muscle and mineral bone mass. Thus, compelling evidence highlights a vicious cycle where male hypogonadism can lead to increased adiposity, while obesity can be a cause for male hypogonadism. On the opposite direction, sustained weight loss can attain amelioration of male gonadal function. In this scenario, a thorough evaluation of gonadal function in men with obesity is crucial to dissect the causes from the consequences in order to target clinical interventions towards maximized improvement of reproductive health. This review will address the causes and consequences of the bidirectional relationship between obesity and hypogonadism, highlighting the implicit male reproductive repercussions.</p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p><strong>CONCLUSION</strong> </p><p>As obesity prevalence increases worldwide, so does the prevalence of worrisome comorbidities increases.<strong> <span style="color: rgb(184, 49, 47)">Obesity‐related hypogonadism </span>is an emerging condition that affects the <span style="color: rgb(184, 49, 47)">quality of life</span>, <span style="color: rgb(184, 49, 47)">disrupts several metabolic functions</span>, and <span style="color: rgb(184, 49, 47)">limits male reproductive potential</span> by <span style="color: rgb(184, 49, 47)">impairing sexual function</span> and <span style="color: rgb(184, 49, 47)">reducing fertility. </span></strong>Moreover, as obesity in young men increases, obesity‐related male infertility is likely to become a serious health issue in the near future. <strong>In addition, obesity and male hypogonadism are intimately related in a manner that one condition perpetuates the other.</strong> Despite the bidirectional relationship between obesity and male hypogonadism, breaking the vicious cycle is undoubtedly achievable, as sustained weight loss allows the reversal of the negative effects of obesity on reproductive function. <strong>These data confer <span style="color: rgb(184, 49, 47)">obesity treatment</span> an imperative status, which can span from <span style="color: rgb(184, 49, 47)">lifestyle modifications</span>, <span style="color: rgb(184, 49, 47)">including caloric‐restriction</span> and <span style="color: rgb(184, 49, 47)">increased physical activity</span> as the backbone of any weight loss intervention, to <span style="color: rgb(184, 49, 47)">pharmacological therapy</span> or even <span style="color: rgb(184, 49, 47)">bariatric surgery</span>, according to the<span style="color: rgb(184, 49, 47)"> severity of obesity</span>.</strong> Nevertheless, further studies are still needed to elucidate the molecular mechanisms behind the vicious cycle of obesity and HPT axis dysfunction. Novel data will then prompt the development of new and more effective interventions and drug therapies in order to dismiss this cycle and achieve optimal clinical outcomes for men with obesity with gonadal and reproductive dysfunction.</p></blockquote><p></p>
[QUOTE="madman, post: 147291, member: 13851"] [B][COLOR=rgb(184, 49, 47)]Summary[/COLOR][/B] Obesity prevalence, particularly in children and young adults, is perilously increasing worldwide foreseeing serious negative health impacts in the future to come. Obesity is linked to impaired male gonadal function and is currently a major cause of hypogonadism. Besides signs and symptoms directly derived from decreased circulating testosterone levels, males with obesity also present poor fertility outcomes, further evidencing the parallelism between obesity and male reproductive function. In addition, males with androgen deficiency also exhibit increased fat accumulation and reduced muscle and mineral bone mass. Thus, compelling evidence highlights a vicious cycle where male hypogonadism can lead to increased adiposity, while obesity can be a cause for male hypogonadism. On the opposite direction, sustained weight loss can attain amelioration of male gonadal function. In this scenario, a thorough evaluation of gonadal function in men with obesity is crucial to dissect the causes from the consequences in order to target clinical interventions towards maximized improvement of reproductive health. This review will address the causes and consequences of the bidirectional relationship between obesity and hypogonadism, highlighting the implicit male reproductive repercussions. [B]CONCLUSION[/B] As obesity prevalence increases worldwide, so does the prevalence of worrisome comorbidities increases.[B] [COLOR=rgb(184, 49, 47)]Obesity‐related hypogonadism [/COLOR]is an emerging condition that affects the [COLOR=rgb(184, 49, 47)]quality of life[/COLOR], [COLOR=rgb(184, 49, 47)]disrupts several metabolic functions[/COLOR], and [COLOR=rgb(184, 49, 47)]limits male reproductive potential[/COLOR] by [COLOR=rgb(184, 49, 47)]impairing sexual function[/COLOR] and [COLOR=rgb(184, 49, 47)]reducing fertility. [/COLOR][/B]Moreover, as obesity in young men increases, obesity‐related male infertility is likely to become a serious health issue in the near future. [B]In addition, obesity and male hypogonadism are intimately related in a manner that one condition perpetuates the other.[/B] Despite the bidirectional relationship between obesity and male hypogonadism, breaking the vicious cycle is undoubtedly achievable, as sustained weight loss allows the reversal of the negative effects of obesity on reproductive function. [B]These data confer [COLOR=rgb(184, 49, 47)]obesity treatment[/COLOR] an imperative status, which can span from [COLOR=rgb(184, 49, 47)]lifestyle modifications[/COLOR], [COLOR=rgb(184, 49, 47)]including caloric‐restriction[/COLOR] and [COLOR=rgb(184, 49, 47)]increased physical activity[/COLOR] as the backbone of any weight loss intervention, to [COLOR=rgb(184, 49, 47)]pharmacological therapy[/COLOR] or even [COLOR=rgb(184, 49, 47)]bariatric surgery[/COLOR], according to the[COLOR=rgb(184, 49, 47)] severity of obesity[/COLOR].[/B] Nevertheless, further studies are still needed to elucidate the molecular mechanisms behind the vicious cycle of obesity and HPT axis dysfunction. Novel data will then prompt the development of new and more effective interventions and drug therapies in order to dismiss this cycle and achieve optimal clinical outcomes for men with obesity with gonadal and reproductive dysfunction. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Obesity and male hypogonadism: Tales of a vicious cycle
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