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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Novel perspectives of Testosterone Therapy in men with functional hypogonadism
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<blockquote data-quote="madman" data-source="post: 272264" data-attributes="member: 13851"><p><strong>ABSTRACT</strong></p><p><strong></strong></p><p><strong>Introduction</strong></p><p></p><p><em>In the past decade, there has been a significant augmentation in the corpus of evidence pertaining to functional hypogonadism. Despite this, prevailing clinical guidelines continue to advise against universal screening for hypogonadism in middle-aged and elderly males. </em></p><p></p><p></p><p><strong>Findings</strong></p><p></p><p><em>Numerous randomized controlled trials have scrutinized the effects of testosterone therapy in males afflicted with type 2 diabetes and/or obesity. However, these guidelines uniformly assert that lifestyle modifications and weight reduction should be the primary intervention strategies in overweight and obese males, relegating testosterone therapy to a secondary, selective option. It is extensively documented that testosterone therapy can yield substantial improvements in various metabolic parameters as well as ameliorate symptoms of erectile dysfunction. Moreover, recent studies have demonstrated the potential of testosterone therapy in reversing type 2 diabetes in males with low-normal testosterone levels who are at elevated risk for this condition, in comparison to the outcomes achievable through lifestyle modifications alone.</em></p><p></p><p></p><p><strong>Conclusion</strong></p><p></p><p><em>This focused review article aims to present a comprehensive update on the latest data concerning the innovative aspects of testosterone therapy in males with functional hypogonadism, particularly in the context of type 2 diabetes and/or obesity. Additionally, it will delve into the cardiovascular safety of such interventions within this high-risk demographic, with a special emphasis on insights gleaned from the TRAVERSE trial.</em></p><p></p><p></p><p></p><p></p><p><strong><em>2. Functional hypogonadism: clinical implications, characteristics, and diagnosis</em></strong></p><p></p><p></p><p><em><strong>3. Benefits of testosterone therapy on parameters of metabolic syndrome</strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong>4. Testosterone therapy for prevention and reversion of type 2 diabetes</strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong>5. Impact of testosterone therapy on bone health</strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong>6. Impact of testosterone therapy on the cardiovascular system</strong></em></p><p></p><p></p><p><strong><em>7. Adverse cardiovascular events and mortality</em></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>8. Conclusion and Clinical Summary</strong></p><p><strong></strong></p><p><strong><em>Men with obesity and/or T2D who experience reduced testosterone levels often face a range of associated health challenges. <u>These can include a decrease in muscle mass and strength, diminished vascular reactivity, reduced coronary blood flow, as well as the presence of anemia and hypertension, all of which are linked to increased mortality</u>. In this context, TTh, particularly when combined with lifestyle modifications, has shown multiple clinical benefits.</em></strong></p><p><strong><em><u>Clinical and observational studies have demonstrated that TTh can effectively decrease fat mass, improve glucose tolerance, and either prevent or reverse recently diagnosed T2D, along with reducing the risk for cardiovascular adverse events</u>. From an epidemiological perspective, the normalization of testosterone concentrations in conjunction with decreased body weight and the improvement or reversal of T2D are associated with favorable cardiometabolic outcomes in men. <u>These findings indicate that TTh could play a significant role in improving overall health outcomes for men with obesity-mediated hypogonadism</u>.</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 272264, member: 13851"] [B]ABSTRACT Introduction[/B] [I]In the past decade, there has been a significant augmentation in the corpus of evidence pertaining to functional hypogonadism. Despite this, prevailing clinical guidelines continue to advise against universal screening for hypogonadism in middle-aged and elderly males. [/I] [B]Findings[/B] [I]Numerous randomized controlled trials have scrutinized the effects of testosterone therapy in males afflicted with type 2 diabetes and/or obesity. However, these guidelines uniformly assert that lifestyle modifications and weight reduction should be the primary intervention strategies in overweight and obese males, relegating testosterone therapy to a secondary, selective option. It is extensively documented that testosterone therapy can yield substantial improvements in various metabolic parameters as well as ameliorate symptoms of erectile dysfunction. Moreover, recent studies have demonstrated the potential of testosterone therapy in reversing type 2 diabetes in males with low-normal testosterone levels who are at elevated risk for this condition, in comparison to the outcomes achievable through lifestyle modifications alone.[/I] [B]Conclusion[/B] [I]This focused review article aims to present a comprehensive update on the latest data concerning the innovative aspects of testosterone therapy in males with functional hypogonadism, particularly in the context of type 2 diabetes and/or obesity. Additionally, it will delve into the cardiovascular safety of such interventions within this high-risk demographic, with a special emphasis on insights gleaned from the TRAVERSE trial.[/I] [B][I]2. Functional hypogonadism: clinical implications, characteristics, and diagnosis[/I][/B] [I][B]3. Benefits of testosterone therapy on parameters of metabolic syndrome 4. Testosterone therapy for prevention and reversion of type 2 diabetes 5. Impact of testosterone therapy on bone health 6. Impact of testosterone therapy on the cardiovascular system[/B][/I] [B][I]7. Adverse cardiovascular events and mortality[/I] 8. Conclusion and Clinical Summary [I]Men with obesity and/or T2D who experience reduced testosterone levels often face a range of associated health challenges. [U]These can include a decrease in muscle mass and strength, diminished vascular reactivity, reduced coronary blood flow, as well as the presence of anemia and hypertension, all of which are linked to increased mortality[/U]. In this context, TTh, particularly when combined with lifestyle modifications, has shown multiple clinical benefits. [U]Clinical and observational studies have demonstrated that TTh can effectively decrease fat mass, improve glucose tolerance, and either prevent or reverse recently diagnosed T2D, along with reducing the risk for cardiovascular adverse events[/U]. From an epidemiological perspective, the normalization of testosterone concentrations in conjunction with decreased body weight and the improvement or reversal of T2D are associated with favorable cardiometabolic outcomes in men. [U]These findings indicate that TTh could play a significant role in improving overall health outcomes for men with obesity-mediated hypogonadism[/U].[/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Novel perspectives of Testosterone Therapy in men with functional hypogonadism
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