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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Not Understanding ED/EOD Protocols
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<blockquote data-quote="Cataceous" data-source="post: 191961" data-attributes="member: 38109"><p>Generally speaking, if you inject a fixed amount of testosterone every week then your average serum testosterone is not going to change much even if you split up the dose in different ways. Technically speaking, the area under the response curves stays about the same. However, the response curves can look dramatically different, and can greatly influence the subjective results. Look at the extremes: If you inject 70 mg T cypionate once a week then after each dose serum testosterone rises rapidly to a high level, then falls pretty steadily over the course of the week until a trough is reached at the next injection. If instead you inject 10 mg every day then serum testosterone stays fairly constant throughout the week; there may be small rises after each injection, but the variation in serum levels is at most a few percent.</p><p></p><p>The perception that 10 mg daily > 70 mg weekly comes from taking trough serum testosterone measurements. With daily injections there are essentially no troughs, so you're simply measuring the average level. Suppose that's 1,000 ng/dL. With weekly injections the trough measurement is much lower, say 500 ng/dL in this example. What most don't see is that high peak in the first day after a weekly injection. In this example it could be as much as 1,500 ng/dL. Only midway through the week does serum testosterone get down to the average level of 1,000 ng/dL.</p><p></p><p>Setting this aside, the basic calculation for matching total dose is most easily done by figuring the dose per day and then multiplying by the number of days in the new proposed cycle. In your case, 40 mg E3D is 40/3 mg per day, or about 13.3 mg. This would be the amount to take on a daily cycle. An EOD cycle has two days, so multiply the daily amount by two, which yields about 26.7 mg. Just keep in mind that on the EOD cycle the trough serum testosterone will be higher than on the E3D cycle. If you want to maintain the same trough then a dose reduction is needed. If you have some pretty consistent total testosterone trough measurements on ED3 then we could come up with a crude estimate of the reduction in dose necessary to maintain the same trough measurements.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 191961, member: 38109"] Generally speaking, if you inject a fixed amount of testosterone every week then your average serum testosterone is not going to change much even if you split up the dose in different ways. Technically speaking, the area under the response curves stays about the same. However, the response curves can look dramatically different, and can greatly influence the subjective results. Look at the extremes: If you inject 70 mg T cypionate once a week then after each dose serum testosterone rises rapidly to a high level, then falls pretty steadily over the course of the week until a trough is reached at the next injection. If instead you inject 10 mg every day then serum testosterone stays fairly constant throughout the week; there may be small rises after each injection, but the variation in serum levels is at most a few percent. The perception that 10 mg daily > 70 mg weekly comes from taking trough serum testosterone measurements. With daily injections there are essentially no troughs, so you're simply measuring the average level. Suppose that's 1,000 ng/dL. With weekly injections the trough measurement is much lower, say 500 ng/dL in this example. What most don't see is that high peak in the first day after a weekly injection. In this example it could be as much as 1,500 ng/dL. Only midway through the week does serum testosterone get down to the average level of 1,000 ng/dL. Setting this aside, the basic calculation for matching total dose is most easily done by figuring the dose per day and then multiplying by the number of days in the new proposed cycle. In your case, 40 mg E3D is 40/3 mg per day, or about 13.3 mg. This would be the amount to take on a daily cycle. An EOD cycle has two days, so multiply the daily amount by two, which yields about 26.7 mg. Just keep in mind that on the EOD cycle the trough serum testosterone will be higher than on the E3D cycle. If you want to maintain the same trough then a dose reduction is needed. If you have some pretty consistent total testosterone trough measurements on ED3 then we could come up with a crude estimate of the reduction in dose necessary to maintain the same trough measurements. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Not Understanding ED/EOD Protocols
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