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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Not tolerating Test Prop?
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<blockquote data-quote="madman" data-source="post: 193414" data-attributes="member: 13851"><p><strong> Pulsatile GnRH Therapy</strong></p><p></p><p><u><strong>Treatment with GnRH requires subcutaneous pulsatile application using a portable pump and a butterfly needle placed in the abdominal wall and changed every 2 days</strong></u><strong>. <u>The dose ranges from 5 to 20 µg/ 120 min, or 100–400 ng/kg body weight per 120 min</u>. <u>Low-dose pulsatile GnRH therapy (2 µg/150 min) may not elicit a sufficient pituitary response, reflecting different degrees of central maturation [16]</u>.</strong> In most cases, the induction of spermatogenesis is evidenced by the appearance of sperm in the ejaculate. Therapy lasts on average 4 months, as shown in six of seven GnRH therapy cycles in patients with idiopathic hypogonadotropic hypogonadism or Kallman syndrome [10]. Sperm counts were below the normal range of 1.2–15.3 mill/ml.</p><p></p><p></p><p><u>When pulsatile GnRH treatment fails, a mutation of the GnRH receptor gene can be the cause</u>. <u>These defects have been described and are probably transmitted as an autosomal recessive trait</u>. A variable degree of hypogonadism in an affected kindred was seen: a male showed no response to pulsatile administration of GnRH, which was effective in his two sisters, all showing clinical patterns of hypogonadotropic hypogonadism [19].</p><p></p><p></p><p><u>Another cause for failure of pulsatile GnRH treatment was observed in a patient who formed anti-GnRH antibodies during intravenous administration</u>. This was associated with deterioration of testosterone and gonadotropin levels [20].</p><p></p><p></p><p></p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/gonadotropin-treatment-in-male-infertility.22552/[/URL]</p><p></p><p><strong>Table 1: Modern modalities of gonadotropin substitution therapy in men to achieve spermatogenesis and maintain androgenicity</strong></p><p><strong>[ATTACH=full]12377[/ATTACH]</strong></p></blockquote><p></p>
[QUOTE="madman, post: 193414, member: 13851"] [B] Pulsatile GnRH Therapy[/B] [U][B]Treatment with GnRH requires subcutaneous pulsatile application using a portable pump and a butterfly needle placed in the abdominal wall and changed every 2 days[/B][/U][B]. [U]The dose ranges from 5 to 20 µg/ 120 min, or 100–400 ng/kg body weight per 120 min[/U]. [U]Low-dose pulsatile GnRH therapy (2 µg/150 min) may not elicit a sufficient pituitary response, reflecting different degrees of central maturation [16][/U].[/B] In most cases, the induction of spermatogenesis is evidenced by the appearance of sperm in the ejaculate. Therapy lasts on average 4 months, as shown in six of seven GnRH therapy cycles in patients with idiopathic hypogonadotropic hypogonadism or Kallman syndrome [10]. Sperm counts were below the normal range of 1.2–15.3 mill/ml. [U]When pulsatile GnRH treatment fails, a mutation of the GnRH receptor gene can be the cause[/U]. [U]These defects have been described and are probably transmitted as an autosomal recessive trait[/U]. A variable degree of hypogonadism in an affected kindred was seen: a male showed no response to pulsatile administration of GnRH, which was effective in his two sisters, all showing clinical patterns of hypogonadotropic hypogonadism [19]. [U]Another cause for failure of pulsatile GnRH treatment was observed in a patient who formed anti-GnRH antibodies during intravenous administration[/U]. This was associated with deterioration of testosterone and gonadotropin levels [20]. [URL unfurl="true"]https://www.excelmale.com/forum/threads/gonadotropin-treatment-in-male-infertility.22552/[/URL] [B]Table 1: Modern modalities of gonadotropin substitution therapy in men to achieve spermatogenesis and maintain androgenicity [ATTACH type="full" alt="Screenshot (3149).png"]12377[/ATTACH][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Not tolerating Test Prop?
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