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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Not tolerating Test Prop?
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<blockquote data-quote="Cataceous" data-source="post: 192978" data-attributes="member: 38109"><p>The GnRH is still part of the protocol, and also the daily 3.2 mg TE/2.4 mg TP. The low-normal LH and FSH I achieve with the GnRH stimulates little, if any endogenous testosterone production. Fortunately it's still enough to provide the benefits of hCG, and then some, without the excessive aromatization. The earlier dosing of ED 3 mg TP / E3D 12.5 mg TE presumably was yielding somewhat higher serum testosterone, but subjectively it was comparable.</p><p></p><p>You interpret TE dosing verbatim. That is, 3.2 mg per day is exactly that. Testosterone content is 72%, so this is providing 2.3 mg pure T per day. The 2.4 mg TP is 83.7% testosterone, so total daily T intake is 4.3 mg, towards the lower end of the normal range of 3-9 mg/day. Translating to serum levels is where it gets interesting, and is dependent on the individual, affected by things like SHBG, metabolic clearance rate, whether steady state has been reached, etc.</p><p></p><p>I have been dosing with a TP/TE combination for over a year. I think the benefits are generally subtle, though I'd expect more significant results in guys who can't find a dosing sweet spot where benefits are present and side effects are minimal. For me at least, the lower testosterone overnight helps with sleep. I have had no problems related to the mixed-ester protocol. The one trade-off I've noticed with decreased dosing in general is in somewhat reduced athleticism. But it's been a worthwhile exchange overall. The 5-day half-life of TE means that daily dosing is not required. That's why I was originally including it only every three days. But in the end it was less work to mix the esters in a separate vial and inject the combination daily. I didn't notice any subjective changes from that, though it's possible there were minor changes to the pharmacokinetics.</p><p></p><p>Measuring serum testosterone when on this mixed-ester protocol is imprecise. The trough levels are likely to be noisy due to the propionate. The peak levels, which for me appear to occur 2-3 hours post-injection, are less noisy, but still nothing like the stability I had on EOD TE. This is why I like the pre-calibration with a longer ester. Once you can say with pretty good confidence that your average free testosterone equals a known constant times your average dose then subsequent measurements are less critical. The main thing in moving to the ester mixture is to figure out your absorption rate for propionate, which then lets you tune the ester ratio. Presumably you have some trough measurements on various doses of TP? If you can figure out your average dose-response to testosterone then you have the information you need.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 192978, member: 38109"] The GnRH is still part of the protocol, and also the daily 3.2 mg TE/2.4 mg TP. The low-normal LH and FSH I achieve with the GnRH stimulates little, if any endogenous testosterone production. Fortunately it's still enough to provide the benefits of hCG, and then some, without the excessive aromatization. The earlier dosing of ED 3 mg TP / E3D 12.5 mg TE presumably was yielding somewhat higher serum testosterone, but subjectively it was comparable. You interpret TE dosing verbatim. That is, 3.2 mg per day is exactly that. Testosterone content is 72%, so this is providing 2.3 mg pure T per day. The 2.4 mg TP is 83.7% testosterone, so total daily T intake is 4.3 mg, towards the lower end of the normal range of 3-9 mg/day. Translating to serum levels is where it gets interesting, and is dependent on the individual, affected by things like SHBG, metabolic clearance rate, whether steady state has been reached, etc. I have been dosing with a TP/TE combination for over a year. I think the benefits are generally subtle, though I'd expect more significant results in guys who can't find a dosing sweet spot where benefits are present and side effects are minimal. For me at least, the lower testosterone overnight helps with sleep. I have had no problems related to the mixed-ester protocol. The one trade-off I've noticed with decreased dosing in general is in somewhat reduced athleticism. But it's been a worthwhile exchange overall. The 5-day half-life of TE means that daily dosing is not required. That's why I was originally including it only every three days. But in the end it was less work to mix the esters in a separate vial and inject the combination daily. I didn't notice any subjective changes from that, though it's possible there were minor changes to the pharmacokinetics. Measuring serum testosterone when on this mixed-ester protocol is imprecise. The trough levels are likely to be noisy due to the propionate. The peak levels, which for me appear to occur 2-3 hours post-injection, are less noisy, but still nothing like the stability I had on EOD TE. This is why I like the pre-calibration with a longer ester. Once you can say with pretty good confidence that your average free testosterone equals a known constant times your average dose then subsequent measurements are less critical. The main thing in moving to the ester mixture is to figure out your absorption rate for propionate, which then lets you tune the ester ratio. Presumably you have some trough measurements on various doses of TP? If you can figure out your average dose-response to testosterone then you have the information you need. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Not tolerating Test Prop?
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