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Thanks for this, insightful as always!

I, too, agree with your synthesis; having been on daily TP for over a year, I find the daily variation excessive. It's bearable, but far from optimal. Are you no longer on the GnRH protocol? Is it correct to understand that you are currently on daily 3.2 TE/2.4 TP? In your view, how does this compare to your previous protocol in this thread (Daily 3 TP / E3D 12.5 TE)?

Curious, how does one generally interpret TE dosing? For instance, in the case of daily 3.2 TE, is it correct to multiply this by 3 to estimate daily level (to account for when TE levels stabilise in c.3 weeks)? If this assumption is correct, your current dosing would translate to 12mg each day. Taking account of the ester, this reduces to 1.992 TP + 6.912 TE = 8.904mg total testosterone per day. Is this thinking correct?

I accept your reasoning for this protocol, that is, to achieve a more normal daily variation, so I am keen to try it! For how long have you been using this method? Have you experienced any issues? Given the long half life of the TE ester, is it necessary to dose daily? Just to add, my SHBG was measured at 22 about two years ago. I've been meaning to get this measured again, but will probably do that after baselining on a new protocol..

Apologies for the string of questions; I don't get the opportunity to change my protocol often. Grateful for the clarity.

<blockquote data-quote="R2D2" data-source="post: 192975" data-attributes="member: 38143">Thanks for this, insightful as always!I, too, agree with your synthesis; having been on daily TP for over a year, I find the daily variation excessive. It&#039;s bearable, but far from optimal. Are you no longer on the GnRH protocol? Is it correct to understand that you are currently on daily 3.2 TE/2.4 TP? In your view, how does this compare to your previous protocol in this thread (Daily 3 TP / E3D 12.5 TE)?Curious, how does one generally interpret TE dosing? For instance, in the case of daily 3.2 TE, is it correct to multiply this by 3 to estimate daily level (to account for when TE levels stabilise in c.3 weeks)? If this assumption is correct, your current dosing would translate to 12mg each day. Taking account of the ester, this reduces to 1.992 TP + 6.912 TE = 8.904mg total testosterone per day. Is this thinking correct?I accept your reasoning for this protocol, that is, to achieve a more normal daily variation, so I am keen to try it! For how long have you been using this method? Have you experienced any issues? Given the long half life of the TE ester, is it necessary to dose daily? Just to add, my SHBG was measured at 22 about two years ago. I&#039;ve been meaning to get this measured again, but will probably do that after baselining on a new protocol..Apologies for the string of questions; I don&#039;t get the opportunity to change my protocol often. Grateful for the clarity.</blockquote>

[QUOTE="R2D2, post: 192975, member: 38143"] Thanks for this, insightful as always! I, too, agree with your synthesis; having been on daily TP for over a year, I find the daily variation excessive. It's bearable, but far from optimal. Are you no longer on the GnRH protocol? Is it correct to understand that you are currently on daily 3.2 TE/2.4 TP? In your view, how does this compare to your previous protocol in this thread (Daily 3 TP / E3D 12.5 TE)? Curious, how does one generally interpret TE dosing? For instance, in the case of daily 3.2 TE, is it correct to multiply this by 3 to estimate daily level (to account for when TE levels stabilise in c.3 weeks)? If this assumption is correct, your current dosing would translate to 12mg each day. Taking account of the ester, this reduces to 1.992 TP + 6.912 TE = 8.904mg total testosterone per day. Is this thinking correct? I accept your reasoning for this protocol, that is, to achieve a more normal daily variation, so I am keen to try it! For how long have you been using this method? Have you experienced any issues? Given the long half life of the TE ester, is it necessary to dose daily? Just to add, my SHBG was measured at 22 about two years ago. I've been meaning to get this measured again, but will probably do that after baselining on a new protocol.. Apologies for the string of questions; I don't get the opportunity to change my protocol often. Grateful for the clarity. [/QUOTE]

Verification

TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038