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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Not tolerating Test Prop?
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<blockquote data-quote="Cataceous" data-source="post: 192946" data-attributes="member: 38109"><p>I see you read my GnRH thread too, which is more reflective of what I've done most of this year. The recap: Except for briefly during the transition period, I didn't do quite as well with daily propionate as with the fairly constant serum levels provided by EOD enanthate. My hypothesis is that the supraphysiological daily fluctuations were too much. The solution was to dampen the variations by mixing enanthate and propionate to better mimic normal daily testosterone variation. This worked well, but it took the addition of GnRH and kisspeptin, and the elimination of hCG to really make me feel more like I did before hypogonadism struck.</p><p></p><p>Dose reductions have been part of this. For me, baseline TRT was taking a total 63 mg enanthate per week, which resulted in fairly constant serum testosterone around 800 ng/dL. This is with SHBG around 30 nMol/L, leading to above-average, though not excessive, free testosterone. Another hypothesis of mine is that the daily peak of testosterone is what provides many of the benefits. This would mean that a protocol giving me a daily peak of 800 ng/dL and a much lower trough would in many ways be comparable to having a constant level of 800 ng/dL. However, this allows for a lower total dose of testosterone, which may help to prevent side effects, such as high estradiol. I've experimented with taking as little as 2.8 mg TE and 2.1 mg TP daily. This is equivalent to only 37 mg T cypionate per week! Yet it still felt ok, and peak testosterone was in the 500s ng/dL. I'm currently at 3.2 mg TE and 2.4 mg TP, putting peak testosterone closer to 700 ng/dL.</p><p></p><p>As for your particular situation, if you're contemplating daily injections anyway then I'd encourage eventually trying a custom enanthate/propionate blend. If you don't have previous experience with fairly constant serum testosterone then a trial with daily TE is useful, both to see what it's like and because it allows you to develop a dose-response relationship. My data show that free testosterone responds very linearly to dose. There are some theoretical reasons to believe this should be true in general. Anyway, this data helps you to estimate the kinds of swings in serum testosterone you can expect when you experiment with various proportions of TE and TP. For me, a ratio by weight of 4 parts TE to 3 parts TP gives a daily variation from peak to trough of around 40%, which is similar to what's seen in normal young men.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 192946, member: 38109"] I see you read my GnRH thread too, which is more reflective of what I've done most of this year. The recap: Except for briefly during the transition period, I didn't do quite as well with daily propionate as with the fairly constant serum levels provided by EOD enanthate. My hypothesis is that the supraphysiological daily fluctuations were too much. The solution was to dampen the variations by mixing enanthate and propionate to better mimic normal daily testosterone variation. This worked well, but it took the addition of GnRH and kisspeptin, and the elimination of hCG to really make me feel more like I did before hypogonadism struck. Dose reductions have been part of this. For me, baseline TRT was taking a total 63 mg enanthate per week, which resulted in fairly constant serum testosterone around 800 ng/dL. This is with SHBG around 30 nMol/L, leading to above-average, though not excessive, free testosterone. Another hypothesis of mine is that the daily peak of testosterone is what provides many of the benefits. This would mean that a protocol giving me a daily peak of 800 ng/dL and a much lower trough would in many ways be comparable to having a constant level of 800 ng/dL. However, this allows for a lower total dose of testosterone, which may help to prevent side effects, such as high estradiol. I've experimented with taking as little as 2.8 mg TE and 2.1 mg TP daily. This is equivalent to only 37 mg T cypionate per week! Yet it still felt ok, and peak testosterone was in the 500s ng/dL. I'm currently at 3.2 mg TE and 2.4 mg TP, putting peak testosterone closer to 700 ng/dL. As for your particular situation, if you're contemplating daily injections anyway then I'd encourage eventually trying a custom enanthate/propionate blend. If you don't have previous experience with fairly constant serum testosterone then a trial with daily TE is useful, both to see what it's like and because it allows you to develop a dose-response relationship. My data show that free testosterone responds very linearly to dose. There are some theoretical reasons to believe this should be true in general. Anyway, this data helps you to estimate the kinds of swings in serum testosterone you can expect when you experiment with various proportions of TE and TP. For me, a ratio by weight of 4 parts TE to 3 parts TP gives a daily variation from peak to trough of around 40%, which is similar to what's seen in normal young men. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Not tolerating Test Prop?
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