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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Not so complex mathematical evidence for why Low Shbg men should inject more often.
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<blockquote data-quote="Cataceous" data-source="post: 210784" data-attributes="member: 38109"><p>Or does it lower androgen levels, which in turn raises SHBG? The amount of androgen reduction seems to be in question. "Metformin has indirect antiandrogenic effects in women with insulin resistance, such as those with PCOS, due to its beneficial effects on insulin sensitivity. It may reduce testosterone levels in such women by as much as 50%. A Cochrane review, though, found that metformin was only slightly effective for decreasing androgen levels in women with PCOS."[<a href="https://en.wikipedia.org/wiki/Metformin#Mechanism_of_action" target="_blank">R</a>]</p><p></p><p>Let's go back to basics. The only thing that matters is whether the overall metabolic clearance rate of testosterone is proportional to free testosterone. This seems likely due to the Law of Mass Action. If you accept this then changing SHBG can have no effect on free testosterone at steady state. I inject 4 mg of testosterone daily. At steady state I must be metabolizing and clearing 4 mg of testosterone daily, no matter what my SHBG. If my clearance rate is proportional to free testosterone then my free testosterone must also be independent of SHBG.</p><p></p><p>In the case of danazol I can only offer the same speculation as with DHT: the underlying metabolic rate constant for testosterone is driven lower, which in turn forces up free testosterone to ensure that the total production rate continues to match the total clearance rate. Alternatively the production rate is driven up, but this seems less likely.</p><p></p><p>You need to clarify what you're saying about SHBG binding to and dissociating from hormones. This occurs constantly, but with the huge numbers involved the macroscopic results follow appropriate statistics to yield predictable concentrations and actions.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 210784, member: 38109"] Or does it lower androgen levels, which in turn raises SHBG? The amount of androgen reduction seems to be in question. "Metformin has indirect antiandrogenic effects in women with insulin resistance, such as those with PCOS, due to its beneficial effects on insulin sensitivity. It may reduce testosterone levels in such women by as much as 50%. A Cochrane review, though, found that metformin was only slightly effective for decreasing androgen levels in women with PCOS."[[URL='https://en.wikipedia.org/wiki/Metformin#Mechanism_of_action']R[/URL]] Let's go back to basics. The only thing that matters is whether the overall metabolic clearance rate of testosterone is proportional to free testosterone. This seems likely due to the Law of Mass Action. If you accept this then changing SHBG can have no effect on free testosterone at steady state. I inject 4 mg of testosterone daily. At steady state I must be metabolizing and clearing 4 mg of testosterone daily, no matter what my SHBG. If my clearance rate is proportional to free testosterone then my free testosterone must also be independent of SHBG. In the case of danazol I can only offer the same speculation as with DHT: the underlying metabolic rate constant for testosterone is driven lower, which in turn forces up free testosterone to ensure that the total production rate continues to match the total clearance rate. Alternatively the production rate is driven up, but this seems less likely. You need to clarify what you're saying about SHBG binding to and dissociating from hormones. This occurs constantly, but with the huge numbers involved the macroscopic results follow appropriate statistics to yield predictable concentrations and actions. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Not so complex mathematical evidence for why Low Shbg men should inject more often.
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