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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Not so complex mathematical evidence for why Low Shbg men should inject more often.
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<blockquote data-quote="xqfq" data-source="post: 210766" data-attributes="member: 38167"><p>I was able to find some studies where metformin is used in PCOS. Conclusion seems to be it raises SHBG and lowers free androgen levels.</p><p></p><p>Here is one that's more directly applicable. Danazol, when given to women, lowers SHBG and increases free testosterone levels:</p><p></p><p>[URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/6682051/[/URL]</p><p></p><p></p><p></p><p>What I can find seems to indicates that SHBG helps control sex steroid availability, not just buffers it. Mechanistically, I can imagine this working in a few different ways.</p><p></p><p>For instance, I can imagine the sex hormones binding to the SHBG, the SBHG then breaking apart / losing the hormones, and then the hormones re-binding to SHBG. So the fact a given hormone might stay bound to SHBG for, let's say, 2 hours, doesn't mean that the hormone is then in a constant state of availability. If it has high binding affinity for SHBG, maybe it could bind SHBG again.</p><p></p><p>In the situation in which SHBG acts entirely as a buffer, we would have to assume that there would be no re-binding of sex hormones after their disassociation? Particularly if there is "more" of SHBG than the sex hormones available.</p><p></p><p>I can imagine that any 'excess' sex hormones, for which there is insufficient SHBG available, that SHBG would act only as a buffer. So there is probably a point at which SHBG would become saturated and the model would shift to where SHBG acts almost entirely as a 'buffer'.</p></blockquote><p></p>
[QUOTE="xqfq, post: 210766, member: 38167"] I was able to find some studies where metformin is used in PCOS. Conclusion seems to be it raises SHBG and lowers free androgen levels. Here is one that's more directly applicable. Danazol, when given to women, lowers SHBG and increases free testosterone levels: [URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/6682051/[/URL] What I can find seems to indicates that SHBG helps control sex steroid availability, not just buffers it. Mechanistically, I can imagine this working in a few different ways. For instance, I can imagine the sex hormones binding to the SHBG, the SBHG then breaking apart / losing the hormones, and then the hormones re-binding to SHBG. So the fact a given hormone might stay bound to SHBG for, let's say, 2 hours, doesn't mean that the hormone is then in a constant state of availability. If it has high binding affinity for SHBG, maybe it could bind SHBG again. In the situation in which SHBG acts entirely as a buffer, we would have to assume that there would be no re-binding of sex hormones after their disassociation? Particularly if there is "more" of SHBG than the sex hormones available. I can imagine that any 'excess' sex hormones, for which there is insufficient SHBG available, that SHBG would act only as a buffer. So there is probably a point at which SHBG would become saturated and the model would shift to where SHBG acts almost entirely as a 'buffer'. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Not so complex mathematical evidence for why Low Shbg men should inject more often.
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