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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Not so complex mathematical evidence for why Low Shbg men should inject more often.
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<blockquote data-quote="Cataceous" data-source="post: 210686" data-attributes="member: 38109"><p>Wouldn't hyperandrogenism tend to cause low SHBG? That is, a regulatory dysfunction results in an overly high set point for androgen production, which suppresses SHBG production in the liver. Insufficient aromatization <a href="https://link.springer.com/article/10.1007/s10549-010-1223-2" target="_blank">does something similar</a>. "Free testosterone significantly increased and sex hormone binding globulin (SHBG) significantly decreased in women on AIs compared to no AIs..."</p><p></p><p>If you treat the hyperandrogenism then SHBG naturally goes up. Give estrogen and that naturally suppresses testosterone production. Higher estrogen and lower testosterone both tend to increase SHBG.</p><p></p><p>First, is there definitive evidence showing this? If it's a real phenomenon then a possible explanation is that the DHT-based steroid lowers the underlying metabolic rate constant of testosterone. Free testosterone is then driven higher because the total clearance rate of testosterone must be maintained to match the input rate.</p><p></p><p>The constancy of SHBG isn't part of the argument. One of the interesting thought experiments is to ask what happens if you could suddenly change the amount of SHBG. In reality SHBG is relatively stable; the half-life is something like a week. There's also research showing little diurnal variation.</p><p></p><p>For less SHBG to imply more free testosterone you must assume total testosterone is constant. But you cannot make this assumption. It's the rate of testosterone production—or absorption with TRT—that we treat as fairly constant. This implies that the total metabolic clearance rate is also fairly constant to match the input. If we accept that free testosterone is proportionally driving metabolic clearance then SHBG is not affecting free testosterone.</p><p></p><p>In the water tub analogy SHBG is not the drain, but it inversely controls the size of the drain; the higher the SHBG the smaller the drain.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 210686, member: 38109"] Wouldn't hyperandrogenism tend to cause low SHBG? That is, a regulatory dysfunction results in an overly high set point for androgen production, which suppresses SHBG production in the liver. Insufficient aromatization [URL='https://link.springer.com/article/10.1007/s10549-010-1223-2']does something similar[/URL]. "Free testosterone significantly increased and sex hormone binding globulin (SHBG) significantly decreased in women on AIs compared to no AIs..." If you treat the hyperandrogenism then SHBG naturally goes up. Give estrogen and that naturally suppresses testosterone production. Higher estrogen and lower testosterone both tend to increase SHBG. First, is there definitive evidence showing this? If it's a real phenomenon then a possible explanation is that the DHT-based steroid lowers the underlying metabolic rate constant of testosterone. Free testosterone is then driven higher because the total clearance rate of testosterone must be maintained to match the input rate. The constancy of SHBG isn't part of the argument. One of the interesting thought experiments is to ask what happens if you could suddenly change the amount of SHBG. In reality SHBG is relatively stable; the half-life is something like a week. There's also research showing little diurnal variation. For less SHBG to imply more free testosterone you must assume total testosterone is constant. But you cannot make this assumption. It's the rate of testosterone production—or absorption with TRT—that we treat as fairly constant. This implies that the total metabolic clearance rate is also fairly constant to match the input. If we accept that free testosterone is proportionally driving metabolic clearance then SHBG is not affecting free testosterone. In the water tub analogy SHBG is not the drain, but it inversely controls the size of the drain; the higher the SHBG the smaller the drain. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Not so complex mathematical evidence for why Low Shbg men should inject more often.
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