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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Not so complex mathematical evidence for why Low Shbg men should inject more often.
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<blockquote data-quote="Cataceous" data-source="post: 210402" data-attributes="member: 38109"><p>Perhaps we make the concept less clear by thinking about discrete doses instead of continuous flows: we give ourselves an injection; we apply a dose of cream, etc. But these still translate to fairly continuous flows of testosterone into circulation. Consider an analogy in which the body is represented as a bathtub with an open drain, into which we're pouring water, which represents testosterone. Total water in the tub is like total testosterone in the body. At steady state the flow out of the tub matches the flow in. The key assumption is that the flow rate out of the tub, governed in this model by the drain size and the water depth, corresponds to the metabolism and excretion of testosterone governed by a proportionality to free testosterone. Now what happens if we increase the drain size, which is equivalent to lowering SHBG? Initially the flow rate out of the drain increases, but over time the water level lowers and the flow decreases to again match the flow rate into the tub. Therefore lowering SHBG while keeping dose and underlying metabolism constant results in lower total testosterone and the same free testosterone. The tub analogy isn't perfect, but I think it's close enough to give us a feel for what's happening.</p><p></p><p>On your specific points: In this theory, TRT dosing drives the total rate of metabolism and excretion, which in turn forces free testosterone to the required level for the rate of use to equal rate of input. This makes total testosterone a dependent variable, just as the water level in the tub analogy can be controlled by the flow rate into the tub. And it is true that men with higher SHBG do not need more testosterone, at least to achieve identical free testosterone to their twins with lower SHBG.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 210402, member: 38109"] Perhaps we make the concept less clear by thinking about discrete doses instead of continuous flows: we give ourselves an injection; we apply a dose of cream, etc. But these still translate to fairly continuous flows of testosterone into circulation. Consider an analogy in which the body is represented as a bathtub with an open drain, into which we're pouring water, which represents testosterone. Total water in the tub is like total testosterone in the body. At steady state the flow out of the tub matches the flow in. The key assumption is that the flow rate out of the tub, governed in this model by the drain size and the water depth, corresponds to the metabolism and excretion of testosterone governed by a proportionality to free testosterone. Now what happens if we increase the drain size, which is equivalent to lowering SHBG? Initially the flow rate out of the drain increases, but over time the water level lowers and the flow decreases to again match the flow rate into the tub. Therefore lowering SHBG while keeping dose and underlying metabolism constant results in lower total testosterone and the same free testosterone. The tub analogy isn't perfect, but I think it's close enough to give us a feel for what's happening. On your specific points: In this theory, TRT dosing drives the total rate of metabolism and excretion, which in turn forces free testosterone to the required level for the rate of use to equal rate of input. This makes total testosterone a dependent variable, just as the water level in the tub analogy can be controlled by the flow rate into the tub. And it is true that men with higher SHBG do not need more testosterone, at least to achieve identical free testosterone to their twins with lower SHBG. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Not so complex mathematical evidence for why Low Shbg men should inject more often.
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