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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
No Link Between Testosterone Levels and Male Pattern Baldness
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<blockquote data-quote="Saxon" data-source="post: 73712" data-attributes="member: 15893"><p><span style="color: #000000"><span style="font-family: 'Times New Roman'">It's DHT: DHT is the cause of Male Pattern Baldness.</span></span></p><p><span style="color: #000000"><span style="font-family: 'Times New Roman'"></span></span></p><p><span style="color: #000000"><span style="font-family: 'Times New Roman'">"The role of androgen in male pattern hair loss is well established. American anatomist James Hamilton observed that castrated males did not develop MAA unless they were supplemented with testosterone (50).</span></span></p><p><span style="color: #000000"><span style="font-family: 'Times New Roman'">Measurements of serum androgens, testosterone, dihydroepiandrosterone sulphate (DHEA), and free testosterone levels have failed to demonstrate a reproducible difference between cases and controls (51). A study that assessed different hormonal levels in MAA and age-matched controls measured elevated levels of cortisol and androstenedione in those experiencing MAA (52). This study further suggests a broad range of hormones may influence androgenetic alopecia. Even though scalp hair loss and hirsutism are essential features of hyperandrogenism in women, several investigations failed to demonstrate raised androgen levels in women (53). Therefore it is suggested that normal levels of androgens are sufficient to cause hair loss in genetically susceptible individuals.</span></span></p><p><span style="color: #000000"><span style="font-family: 'Times New Roman'">The observation that eunuchoidal patients with androgen-insensitivity syndrome and 5 alpha-reductase deficiency do not go bald suggests that MAA is induced by activation of follicular androgen receptors by DHT (54-56). Patients affected by Kennedy's disease, with a functional abnormality of the androgen receptor gene, have a reduced risk of MAA (57). Increased levels of DHT have been found in balding scalp compared to non-balding scalp (58).</span></span></p><p><span style="color: #000000"><span style="font-family: 'Times New Roman'">Intrafollicular androgen over-activity may also be the result of local factors including an increased number of androgen receptors, functional polymorphisms of the androgen receptor, increased local production of DHT, and reduced local degradation of DHT (59)."</span></span></p><p><span style="color: #000000"><span style="font-family: 'Times New Roman'"></span></span></p><p><span style="color: #000000"><span style="font-family: 'Times New Roman'">Great Article: </span></span></p><p><span style="color: #000000"><span style="font-family: 'Times New Roman'"><a href="https://www.ncbi.nlm.nih.gov/books/NBK278957/" target="_blank">https://www.ncbi.nlm.nih.gov/books/NBK278957/</a></span></span></p></blockquote><p></p>
[QUOTE="Saxon, post: 73712, member: 15893"] [COLOR=#000000][FONT=Times New Roman]It's DHT: DHT is the cause of Male Pattern Baldness. "The role of androgen in male pattern hair loss is well established. American anatomist James Hamilton observed that castrated males did not develop MAA unless they were supplemented with testosterone (50).[/FONT][/COLOR] [COLOR=#000000][FONT=Times New Roman]Measurements of serum androgens, testosterone, dihydroepiandrosterone sulphate (DHEA), and free testosterone levels have failed to demonstrate a reproducible difference between cases and controls (51). A study that assessed different hormonal levels in MAA and age-matched controls measured elevated levels of cortisol and androstenedione in those experiencing MAA (52). This study further suggests a broad range of hormones may influence androgenetic alopecia. Even though scalp hair loss and hirsutism are essential features of hyperandrogenism in women, several investigations failed to demonstrate raised androgen levels in women (53). Therefore it is suggested that normal levels of androgens are sufficient to cause hair loss in genetically susceptible individuals.[/FONT][/COLOR] [COLOR=#000000][FONT=Times New Roman]The observation that eunuchoidal patients with androgen-insensitivity syndrome and 5 alpha-reductase deficiency do not go bald suggests that MAA is induced by activation of follicular androgen receptors by DHT (54-56). Patients affected by Kennedy's disease, with a functional abnormality of the androgen receptor gene, have a reduced risk of MAA (57). Increased levels of DHT have been found in balding scalp compared to non-balding scalp (58).[/FONT][/COLOR] [COLOR=#000000][FONT=Times New Roman]Intrafollicular androgen over-activity may also be the result of local factors including an increased number of androgen receptors, functional polymorphisms of the androgen receptor, increased local production of DHT, and reduced local degradation of DHT (59)." Great Article: [url]https://www.ncbi.nlm.nih.gov/books/NBK278957/[/url][/FONT][/COLOR] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
No Link Between Testosterone Levels and Male Pattern Baldness
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