For a lot of us it was simple trial and error. We started using a reasonable amount of Pregenolone and if we felt better, we kept using it. For me, I have in the past had sleeping issues and Pregnenolone before bed (10mg via cream) helps me relax and go to sleep.
I too would prefer to have hard data to back this up, but sometimes one has to experiment as each of us often respond so differently.
