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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Nipple sensitivity
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<blockquote data-quote="JohnTaylorHK" data-source="post: 138750" data-attributes="member: 33105"><p>No Sir, in actual fact if you take exogenous T then endogenous T production is reduced, a double whammy for hypogonadism sufferers. Assuming you are doing a gluteal IM, then 50% of whatever quantity you inject will be metabolized within the specified half-life. After a further half-life period, another 50% (25% of the original amount) will be metabolized and so on. So the circulating T follows an exponential decline. Now if you add the same amount after the first half-life period, you will actually raise the circulating T again. Now you have 2 "components", both decaying at the same rate. If you graph this decline, you will see that it is NOT optimal, there is a greater opportunity to "smooth out" the associated peaks and troughs of the circulating T, ensuring a (more or less) steady level. The way to do this is to decide what circulating level you want, and then use 2 doses to achieve that. After the half-life lapses, use a single dose per half-life period. I have a spreadsheet which I created a few years ago, which may help someone. Sadly this forum will not allow me to upload it. PM me if you would like a copy. Namaste</p></blockquote><p></p>
[QUOTE="JohnTaylorHK, post: 138750, member: 33105"] No Sir, in actual fact if you take exogenous T then endogenous T production is reduced, a double whammy for hypogonadism sufferers. Assuming you are doing a gluteal IM, then 50% of whatever quantity you inject will be metabolized within the specified half-life. After a further half-life period, another 50% (25% of the original amount) will be metabolized and so on. So the circulating T follows an exponential decline. Now if you add the same amount after the first half-life period, you will actually raise the circulating T again. Now you have 2 "components", both decaying at the same rate. If you graph this decline, you will see that it is NOT optimal, there is a greater opportunity to "smooth out" the associated peaks and troughs of the circulating T, ensuring a (more or less) steady level. The way to do this is to decide what circulating level you want, and then use 2 doses to achieve that. After the half-life lapses, use a single dose per half-life period. I have a spreadsheet which I created a few years ago, which may help someone. Sadly this forum will not allow me to upload it. PM me if you would like a copy. Namaste [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Nipple sensitivity
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