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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Newbie confused by prescription, help please
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<blockquote data-quote="RobRoy" data-source="post: 206700" data-attributes="member: 42893"><p>Not wanting to open up that can of worms but Dr. Sayas Concerns are not based on current medical literature. There are 3TRT myths that are continually propagated. The first myth is that it causes prostate cancer. It is also a myth that it worsens prostate cancer in men with prostate cancer. The second myth is that you have to control estrogen. No available literature shows that blocking estrogen is beneficial but in fact there is plenty of medical literature to show the harm. The majority of testosterones benefits come From its conversion into estradiol. Dr. Rouzier and physicians like him that treat men and don’t block estradiol don’t have patients with so-called estrogen symptoms. With increasing androgens the androgen to estradiol ratio increases or said another way the Estradiol To Testosterone ratio decreases. That is because there’s only so much aromatase enzyme in each man and there comes a point where the increase in androgens the enzyme is fully saturated and reaches its v max. So estradiol reaches a point that it cannot rise any further because the aromatase enzyme is fully saturated but the androgen level will continue to increase with increasing dosages.</p><p></p><p>The third myth is that it causes heart attacks strokes and blood clots because of increasing hematocrit. Testosterone is not polycythemia vera which increases Hematocrit along with platelets. In polycythemia vera there is both a quantitative and qualitative problem with red blood cells which is not seen in TRT. If one purely focuses on the raising hematocrit scene with TRT then one would falsely believe there is harm. What happens in lab experience using inflexible viscometer‘s it’s not what happens in the human body. People that take a myopic view Of hematocrit completely ignore all of the other positive effects on the vasculature from testosterone. Testosterone has great influence on vascular reactivity and this positive influence counteracts any increase in viscosity. The fact that testosterone has been used and abused by millions of men worldwide and many of them not under the treatment other physician and getting no lab work and yet there has been no increase in heart attacks strokes or blood clots. There has not been one single randomized controlled trial since testosterone was discovered, and there have been thousands done, that showed an increase risk of heart attacks strokes or blood clots in men. You can continue to think that it does if you just want to focus on hematocrit but it doesn’t…once again Because of all the other positive effects testosterone has On vascular reactivity. And believe it or not those positive affects Are mediated through Estradiol. So testosterone once again has been used and abused for many decades and yet no harm has been seen. The normal range for men is not a healthy range. It’s simply the reference range for a population of men with a BMI less than 30. There was no evaluation for health or symptoms of testosterone deficiency. There’s nothing harmful about being super physiologic which now means anything greater than 916 ng/dL.</p><p></p><p>So as I said before I really don’t have time for forums anymore But what all of you should be asking it’s for those that say testosterone is harmful and that hematocrit must be managed and that estradiol must be managed is for them to provide actual randomized controlled trial’swhere testosterone caused harm. I can provide you with dozens upon dozens of studies showing the benefits of testosterone even in the worst of men with congested heart failure, Previous MIs , angina pectoris, Obesity And yet it caused no harm in any of the studies And amazingly and everyone of these studies estrogen I was not controlled Nor were men undergoing phlebotomies. People want to ignore the history of testosterone and how men were treated in the early days before lab testing. They were treated with testosterone without labs until symptoms improved and amazingly no harm was done.</p></blockquote><p></p>
[QUOTE="RobRoy, post: 206700, member: 42893"] Not wanting to open up that can of worms but Dr. Sayas Concerns are not based on current medical literature. There are 3TRT myths that are continually propagated. The first myth is that it causes prostate cancer. It is also a myth that it worsens prostate cancer in men with prostate cancer. The second myth is that you have to control estrogen. No available literature shows that blocking estrogen is beneficial but in fact there is plenty of medical literature to show the harm. The majority of testosterones benefits come From its conversion into estradiol. Dr. Rouzier and physicians like him that treat men and don’t block estradiol don’t have patients with so-called estrogen symptoms. With increasing androgens the androgen to estradiol ratio increases or said another way the Estradiol To Testosterone ratio decreases. That is because there’s only so much aromatase enzyme in each man and there comes a point where the increase in androgens the enzyme is fully saturated and reaches its v max. So estradiol reaches a point that it cannot rise any further because the aromatase enzyme is fully saturated but the androgen level will continue to increase with increasing dosages. The third myth is that it causes heart attacks strokes and blood clots because of increasing hematocrit. Testosterone is not polycythemia vera which increases Hematocrit along with platelets. In polycythemia vera there is both a quantitative and qualitative problem with red blood cells which is not seen in TRT. If one purely focuses on the raising hematocrit scene with TRT then one would falsely believe there is harm. What happens in lab experience using inflexible viscometer‘s it’s not what happens in the human body. People that take a myopic view Of hematocrit completely ignore all of the other positive effects on the vasculature from testosterone. Testosterone has great influence on vascular reactivity and this positive influence counteracts any increase in viscosity. The fact that testosterone has been used and abused by millions of men worldwide and many of them not under the treatment other physician and getting no lab work and yet there has been no increase in heart attacks strokes or blood clots. There has not been one single randomized controlled trial since testosterone was discovered, and there have been thousands done, that showed an increase risk of heart attacks strokes or blood clots in men. You can continue to think that it does if you just want to focus on hematocrit but it doesn’t…once again Because of all the other positive effects testosterone has On vascular reactivity. And believe it or not those positive affects Are mediated through Estradiol. So testosterone once again has been used and abused for many decades and yet no harm has been seen. The normal range for men is not a healthy range. It’s simply the reference range for a population of men with a BMI less than 30. There was no evaluation for health or symptoms of testosterone deficiency. There’s nothing harmful about being super physiologic which now means anything greater than 916 ng/dL. So as I said before I really don’t have time for forums anymore But what all of you should be asking it’s for those that say testosterone is harmful and that hematocrit must be managed and that estradiol must be managed is for them to provide actual randomized controlled trial’swhere testosterone caused harm. I can provide you with dozens upon dozens of studies showing the benefits of testosterone even in the worst of men with congested heart failure, Previous MIs , angina pectoris, Obesity And yet it caused no harm in any of the studies And amazingly and everyone of these studies estrogen I was not controlled Nor were men undergoing phlebotomies. People want to ignore the history of testosterone and how men were treated in the early days before lab testing. They were treated with testosterone without labs until symptoms improved and amazingly no harm was done. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Newbie confused by prescription, help please
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