ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Newbie confused by prescription, help please
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Fortunate" data-source="post: 206479" data-attributes="member: 42264"><p>I don't want to hijack this thread, so hopefully these comments and questions will be beneficial.</p><p></p><p>I have had some serious roller coaster rides on cream a few times. I vow not to try it again, only to grow curious and try it all over. However, I have been somewhat methodical about my approach and I have kept a log detailing how much I am using, where it's applied and how I respond to it. Looking at my log over the last months, I have tried cream a number of times, but with every attempt, I was applying at least some to the scrotum. But, it appears that I have not done exclusively trunk or arm application, and this might be significant.</p><p></p><p>[USER=38109]@Cataceous[/USER] has posted information on the average amount of testosterone a healthy male makes per day (can't remember the number, but it's single digits in mg). In theory, we should replace 7-10mg per day (roughly). The package insert for Androgel states the various strengths (5G, 7.5G and 10G) have 50mg, 75mg and 100mg of testosterone, respectively. They further state that about 10% of the applied testosterone is absorbed. Therefore, the patient is getting 5mg, 7.5mg or 10mg per day of testosterone.</p><p></p><p>This begs the question: Why are compounding pharmacies making creams that are twice as concentrated as Androgel, if Androgel's absorption numbers are accurate? The concept of scrotal application makes this even more confusing.</p><p></p><p>Several here reference an article published in Andrology that demonstrates an estimated 8-fold increase in absorption of cream when applied to the scrotum compared to other areas. Admittedly, I am not sure if this is a calculated estimate or a direct measurement. That said, if this is true, wouldn't that suggest that with scrotal application, you would absorb 8x5 (40), 8x7.5 (60) and 8x10 (100)mg respectively? That's up to ten times what you are trying to replace. And, this is not considering a hydrogel carrier, which supposedly improves absorption even further (I don't think that study used hydrogel, but can't confirm with certainty). </p><p></p><p>Someone smarter than me please tell me, are my numbers correct? Even if some assumptions are not totally accurate, numbers even remotely close to being that high would explain why I got so over the top every time I tried cream. Maybe I need to simply apply 75mg to the shoulders to get my 7.5mg and call it a day?!?!</p></blockquote><p></p>
[QUOTE="Fortunate, post: 206479, member: 42264"] I don't want to hijack this thread, so hopefully these comments and questions will be beneficial. I have had some serious roller coaster rides on cream a few times. I vow not to try it again, only to grow curious and try it all over. However, I have been somewhat methodical about my approach and I have kept a log detailing how much I am using, where it's applied and how I respond to it. Looking at my log over the last months, I have tried cream a number of times, but with every attempt, I was applying at least some to the scrotum. But, it appears that I have not done exclusively trunk or arm application, and this might be significant. [USER=38109]@Cataceous[/USER] has posted information on the average amount of testosterone a healthy male makes per day (can't remember the number, but it's single digits in mg). In theory, we should replace 7-10mg per day (roughly). The package insert for Androgel states the various strengths (5G, 7.5G and 10G) have 50mg, 75mg and 100mg of testosterone, respectively. They further state that about 10% of the applied testosterone is absorbed. Therefore, the patient is getting 5mg, 7.5mg or 10mg per day of testosterone. This begs the question: Why are compounding pharmacies making creams that are twice as concentrated as Androgel, if Androgel's absorption numbers are accurate? The concept of scrotal application makes this even more confusing. Several here reference an article published in Andrology that demonstrates an estimated 8-fold increase in absorption of cream when applied to the scrotum compared to other areas. Admittedly, I am not sure if this is a calculated estimate or a direct measurement. That said, if this is true, wouldn't that suggest that with scrotal application, you would absorb 8x5 (40), 8x7.5 (60) and 8x10 (100)mg respectively? That's up to ten times what you are trying to replace. And, this is not considering a hydrogel carrier, which supposedly improves absorption even further (I don't think that study used hydrogel, but can't confirm with certainty). Someone smarter than me please tell me, are my numbers correct? Even if some assumptions are not totally accurate, numbers even remotely close to being that high would explain why I got so over the top every time I tried cream. Maybe I need to simply apply 75mg to the shoulders to get my 7.5mg and call it a day?!?! [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Newbie confused by prescription, help please
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top