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<blockquote data-quote="madman" data-source="post: 179818" data-attributes="member: 13851"><p>As you know it would be impossible to truly gauge how you feel overall seeing as you changed your dose so frequently within the first 4 months of starting trt because any time one injects exogenous esterified T hormones will be in FLUX in the following weeks leading up until levels stabilize at 4-6 weeks and even then once levels have stabilized it will take 2-3 months for the body to adapt to the new T level.</p><p></p><p>Once blood work is done at 6 weeks if TT/FT/e2 levels are in a healthy range than during the next 2-3 months is the critical time period when one should truly gauge how they feel overall regarding relief/improvement of low-t symptoms (mood/energy/libido/erectile function/body composition/recovery).</p><p></p><p>Otherwise, you will just end up running around in circles chasing your own tail.</p><p></p><p>The goal is to achieve a healthy TT/FT level which will allow you to reap the positive beneficial effect of testosterone while also minimizing any potential negative side-effects and keeping blood markers in a healthy range.</p><p></p><p>Although treating symptoms is what truly matters labs are critical not only to make sure blood markers are healthy but also to see where the patient's TT/FT level among other hormones end up on the said dose of T as they can be too low or too high resulting in lack of overall improvement.</p><p></p><p>Blood testing should include SHBG, estradiol, and free testosterone.</p><p></p><p>Unfortunately, there are many doctors who only tend to test TT levels without even looking at the patient's SHBG or estradiol let alone FT.</p><p></p><p>Free testosterone is what truly matters as it is the active unbound fraction of testosterone that is responsible for the positive effects.</p><p></p><p>Another big problem in Canada is we do not have access to accurate methods for testing such as the gold standard Equilibrium Dialysis (most accurate) or Ultrafiltration (next best).</p><p></p><p>For the longest time labs were using the direct immunoassay/tracer analog which was inaccurate and is no longer recommended.</p><p></p><p>Within the past 4 years, they replaced the direct test with the linear law-of-mass action calculated Vermuelen method which also has its own flaws.</p><p></p><p>The only way you are ever going to know where FT levels truly sit is to order a blood test through Nelson's Discountlabs and cross over the border to the US to have your blood work done at a Lab that offers the most accurate testing methods for FT (ED/UF).</p></blockquote><p></p>
[QUOTE="madman, post: 179818, member: 13851"] As you know it would be impossible to truly gauge how you feel overall seeing as you changed your dose so frequently within the first 4 months of starting trt because any time one injects exogenous esterified T hormones will be in FLUX in the following weeks leading up until levels stabilize at 4-6 weeks and even then once levels have stabilized it will take 2-3 months for the body to adapt to the new T level. Once blood work is done at 6 weeks if TT/FT/e2 levels are in a healthy range than during the next 2-3 months is the critical time period when one should truly gauge how they feel overall regarding relief/improvement of low-t symptoms (mood/energy/libido/erectile function/body composition/recovery). Otherwise, you will just end up running around in circles chasing your own tail. The goal is to achieve a healthy TT/FT level which will allow you to reap the positive beneficial effect of testosterone while also minimizing any potential negative side-effects and keeping blood markers in a healthy range. Although treating symptoms is what truly matters labs are critical not only to make sure blood markers are healthy but also to see where the patient's TT/FT level among other hormones end up on the said dose of T as they can be too low or too high resulting in lack of overall improvement. Blood testing should include SHBG, estradiol, and free testosterone. Unfortunately, there are many doctors who only tend to test TT levels without even looking at the patient's SHBG or estradiol let alone FT. Free testosterone is what truly matters as it is the active unbound fraction of testosterone that is responsible for the positive effects. Another big problem in Canada is we do not have access to accurate methods for testing such as the gold standard Equilibrium Dialysis (most accurate) or Ultrafiltration (next best). For the longest time labs were using the direct immunoassay/tracer analog which was inaccurate and is no longer recommended. Within the past 4 years, they replaced the direct test with the linear law-of-mass action calculated Vermuelen method which also has its own flaws. The only way you are ever going to know where FT levels truly sit is to order a blood test through Nelson's Discountlabs and cross over the border to the US to have your blood work done at a Lab that offers the most accurate testing methods for FT (ED/UF). [/QUOTE]
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