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"Estradiol, Free" should be a crucial part of your labs with low SHBG, Estrogen will be your largest challenge, and moderating your dose to control how much Free T you have. We know SHBG binds (or not) to E just like it does for T. Thus the more Free T you have the more Free E (should) be present for you. You'll likely need to run much lower E per the LC/MS/MS test...I run mine in the single digits and I'm better than I ever have been...my SHBG is 12.