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Diggs - With the horror stories we read on this site, the senior members are always telling guys to seek a competent doctor to help them with therapy. It appears you've done that as this guy is widely considered to be one of the best. But I just can't imagine why he would have you on such a high dose of anastrozole. It's mind-boggling to me. We all know we're different, but I'm currently taking 1/8 mg of Anastrozole twice a week and I can feel the difference if I miss a dose. That's how powerful this drug is.