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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
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<blockquote data-quote="madman" data-source="post: 139352" data-attributes="member: 13851"><p>Of course there is still going to be a daily peak/trough with prop but understand that even when using prop daily the troughs are going to be minimal and are in no way comparable to the the 24 hr circadian rhythm of a healthy young male endogenous testosterone levels.</p><p></p><p>Within 2 hrs of injecting prop T levels are increasing and peak at 12-14 hr and stay elevated for up to 24 hrs before declining and even though there is going to be fluctuations during those 24 hrs there is not going to be a drastic drop in T levels during that time.....compared to injecting prop EOD where there will be a much bigger difference between peak/trough levels as due to the pharmacokinetics of propionate levels decline much more rapidly 24-36 hrs post injection.</p><p></p><p>Naturally endogenous levels peak in the early am and than decline in the late afternoon/early evening (trough) and there can be up to a 30-40% difference between peak/trough levels.</p><p></p><p>Average healthy young males have a TT of 600-800 ng/dL at peak and T levels are much lower at trough on a daily basis.</p><p></p><p>When on trt regardless of ester used whether injecting daily most men are running 1000+ TT levels and although there is still a peak/trough even with daily most still have a trough level well into the high end of the physiological range as when injecting daily the difference between peak/trough is not extreme as daily results in the most stable levels although there are still fluctuations.</p><p></p><p>So even with daily prop.....sure you are getting the benefit of the earlier peak compared to enanthate/cypionate but you are in no way mimicking some form of natural diurnal rhythm.</p><p></p><p>All that said as we know not only dose of T/injection frequency effect the difference between peak/trough levels but most importantly ones SHBG.</p></blockquote><p></p>
[QUOTE="madman, post: 139352, member: 13851"] Of course there is still going to be a daily peak/trough with prop but understand that even when using prop daily the troughs are going to be minimal and are in no way comparable to the the 24 hr circadian rhythm of a healthy young male endogenous testosterone levels. Within 2 hrs of injecting prop T levels are increasing and peak at 12-14 hr and stay elevated for up to 24 hrs before declining and even though there is going to be fluctuations during those 24 hrs there is not going to be a drastic drop in T levels during that time.....compared to injecting prop EOD where there will be a much bigger difference between peak/trough levels as due to the pharmacokinetics of propionate levels decline much more rapidly 24-36 hrs post injection. Naturally endogenous levels peak in the early am and than decline in the late afternoon/early evening (trough) and there can be up to a 30-40% difference between peak/trough levels. Average healthy young males have a TT of 600-800 ng/dL at peak and T levels are much lower at trough on a daily basis. When on trt regardless of ester used whether injecting daily most men are running 1000+ TT levels and although there is still a peak/trough even with daily most still have a trough level well into the high end of the physiological range as when injecting daily the difference between peak/trough is not extreme as daily results in the most stable levels although there are still fluctuations. So even with daily prop.....sure you are getting the benefit of the earlier peak compared to enanthate/cypionate but you are in no way mimicking some form of natural diurnal rhythm. All that said as we know not only dose of T/injection frequency effect the difference between peak/trough levels but most importantly ones SHBG. [/QUOTE]
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