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Health & Wellness
New Research Confirms We Got Cholesterol All Wrong
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<blockquote data-quote="dnfuss" data-source="post: 123773" data-attributes="member: 15487"><p>Agreed. No statistically significant benefit from taking statins <u>except</u> in middle-aged males with existing cardiovascular disease (secondary prevention), and even there a very weak association (very high NNT). No benefit whatsoever in women or the old, even if they've already had a heart attack, and no benefit for <u>anyone</u> for primary prevention. What little benefit they may actually provide is clearly not related to any lowering of lipid labs.</p><p></p><p></p><p></p><p>I believe Dr. Kendrick's view (which I share) would be that all of the various lipid labs are basically irrelevant, that they have no value in terms of either prediction or prevention of cardiovascular disease (e.g., the average LDL of heart attack victims is no higher than that of those who don't have heart attacks), and that this endless switching of focus on what is the cholesterol marker to watch (from total cholesterol, to LDL, to particle size, to particle number) is simply an attempt to make a square peg fit into a round hole. There may be an association between any of these lab values and cardiovascular disease (although it is often later proven to be a very weak association, if any), but it is a case of firemen at the fire. Lipoproteins are found in aortic plaques because they're involved in the body's attempt to repair the damaged endothelium. The lipoproteins aren't causing the damage. Therefore lowering their number isn't going to prevent/cure it.</p></blockquote><p></p>
[QUOTE="dnfuss, post: 123773, member: 15487"] Agreed. No statistically significant benefit from taking statins [U]except[/U] in middle-aged males with existing cardiovascular disease (secondary prevention), and even there a very weak association (very high NNT). No benefit whatsoever in women or the old, even if they've already had a heart attack, and no benefit for [U]anyone[/U] for primary prevention. What little benefit they may actually provide is clearly not related to any lowering of lipid labs. I believe Dr. Kendrick's view (which I share) would be that all of the various lipid labs are basically irrelevant, that they have no value in terms of either prediction or prevention of cardiovascular disease (e.g., the average LDL of heart attack victims is no higher than that of those who don't have heart attacks), and that this endless switching of focus on what is the cholesterol marker to watch (from total cholesterol, to LDL, to particle size, to particle number) is simply an attempt to make a square peg fit into a round hole. There may be an association between any of these lab values and cardiovascular disease (although it is often later proven to be a very weak association, if any), but it is a case of firemen at the fire. Lipoproteins are found in aortic plaques because they're involved in the body's attempt to repair the damaged endothelium. The lipoproteins aren't causing the damage. Therefore lowering their number isn't going to prevent/cure it. [/QUOTE]
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New Research Confirms We Got Cholesterol All Wrong
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