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New on Excelmale. 3 years on trt. Need help with getting dialed in!
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<blockquote data-quote="Cataceous" data-source="post: 140006" data-attributes="member: 38109"><p>It's possible your high estradiol is holding you back. Your calculated free estradiol is around 2.3 pg/mL. The top of the normal range is more like 1.5 pg/mL. It's admirable that you've held off on using an AI, but it may be time to reconsider that.</p><p></p><p>It's not ideal that you haven't been able to verify the estradiol measurements with a mass spectrometry-based test. But the numbers are high enough that even with significant cross-reactivity in the test you're likely still well above the normal range.</p><p></p><p>Do you have access to a shorter testosterone ester, such as propionate or enanthate? Since you don't seem to mind frequent injections, using a short single ester would allow for faster evaluations of protocol changes.</p><p></p><p>If you do start an AI, low and slow is the rule. Even though you appear to have excess aromatase activity, you may still be quite sensitive to these drugs. You don't want to push estradiol too low, which can be worse than too high.</p><p></p><p>BTW, individual testosterone measurements can vary quite a lot, so I wouldn't worry about the inconsistency in getting a lower reading after raising the dose.</p><p></p><p>Another thing to consider is adding hCG, which is sometimes helpful when TRT alone isn't sufficient. But I would experiment with lower estradiol first, due to hCG's propensity to raise it.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 140006, member: 38109"] It's possible your high estradiol is holding you back. Your calculated free estradiol is around 2.3 pg/mL. The top of the normal range is more like 1.5 pg/mL. It's admirable that you've held off on using an AI, but it may be time to reconsider that. It's not ideal that you haven't been able to verify the estradiol measurements with a mass spectrometry-based test. But the numbers are high enough that even with significant cross-reactivity in the test you're likely still well above the normal range. Do you have access to a shorter testosterone ester, such as propionate or enanthate? Since you don't seem to mind frequent injections, using a short single ester would allow for faster evaluations of protocol changes. If you do start an AI, low and slow is the rule. Even though you appear to have excess aromatase activity, you may still be quite sensitive to these drugs. You don't want to push estradiol too low, which can be worse than too high. BTW, individual testosterone measurements can vary quite a lot, so I wouldn't worry about the inconsistency in getting a lower reading after raising the dose. Another thing to consider is adding hCG, which is sometimes helpful when TRT alone isn't sufficient. But I would experiment with lower estradiol first, due to hCG's propensity to raise it. [/QUOTE]
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How to Use This Forum and Introductions
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New on Excelmale. 3 years on trt. Need help with getting dialed in!
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