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<blockquote data-quote="FunkOdyssey" data-source="post: 270422" data-attributes="member: 44064"><p>If you could dissociate a bunch of SHBG from testosterone and remove the SHBG from your body, yes, you would have more free testosterone at that precise moment. Your body is regulating testosterone production based on Free T and E2 though, to keep those hormones at the desired level. If a flood of free T came out of nowhere by crushing your SHBG, your production would slow down or stop until the free T was metabolized. Your new lower SHBG self would find homeostasis at the original free T level and the only change is your total T would now be reduced. You wouldn't feel any different, because your signs and symptoms of eugonadism or hypogonadism are driven by free T, which hasn't changed.</p><p></p><p></p><p>It is pretty accurate actually. Your calculated value used the Vermeulen formula which we know is pretty damn good. It's better than an inaccurate direct assay for free T. It is also allowing you to compare apples to apples with most other men who are also using the same calculation to derive a free T value.</p><p></p><p>The only thing better than the Vermeulen calculated free T is to measure it with an accurate test like equilibrium dialysis.</p></blockquote><p></p>
[QUOTE="FunkOdyssey, post: 270422, member: 44064"] If you could dissociate a bunch of SHBG from testosterone and remove the SHBG from your body, yes, you would have more free testosterone at that precise moment. Your body is regulating testosterone production based on Free T and E2 though, to keep those hormones at the desired level. If a flood of free T came out of nowhere by crushing your SHBG, your production would slow down or stop until the free T was metabolized. Your new lower SHBG self would find homeostasis at the original free T level and the only change is your total T would now be reduced. You wouldn't feel any different, because your signs and symptoms of eugonadism or hypogonadism are driven by free T, which hasn't changed. It is pretty accurate actually. Your calculated value used the Vermeulen formula which we know is pretty damn good. It's better than an inaccurate direct assay for free T. It is also allowing you to compare apples to apples with most other men who are also using the same calculation to derive a free T value. The only thing better than the Vermeulen calculated free T is to measure it with an accurate test like equilibrium dialysis. [/QUOTE]
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