With the shrinkage some guys can have some pain so that's not unusual and is a primary reason to not have what amounts to an induced organ failure, which is what is happening with shrinkage.
Do you have a new set of labs? Nothing since Apr? Your numbers you did post are just way too high (Apr) but you should have some new labs due. Dosing should be based off your Free T and not the TT.
When my Estrogen was too high, too high for ME, I was all broken out with bacne and my nuts were tighter to the body. That doesn't mean that's true for you though.
Also note there is only one acceptable test for E in males which is "sensitive Estradiol LC/MS/MS" any other is for females and should not be used.