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New member - 33yo recently starting TRT
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<blockquote data-quote="Cataceous" data-source="post: 213653" data-attributes="member: 38109"><p>One of the perils of coming to the forums for advice is that you will get a lot of different recommendations and information, sometimes quite contradictory.</p><p></p><p>The half-life of testosterone cypionate in standard formulations is actually closer to five days, and typically one waits at least four to five half-lives before trying to see what serum levels are doing. Overall effects certainly can take a lot longer:</p><p>[URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188848/[/URL]</p><p></p><p>A starting dose of 50 mg TC per week is low but not unreasonably so. It's an average of 5 mg of testosterone per day, which compares to the 6-7 mg averaged naturally by healthy young men. Personally I've averaged as little as 3.8 mg per day without feeling hypogonadal. The bigger problem is the injection frequency. With weekly injections there are often large variations in serum hormone levels, with peak levels two to three times trough levels. This is what makes a lower dose untenable; the last day or two of each injection cycle will most likely be spent at hypogonadal testosterone levels. The preferred solution is to inject more often. At larger doses you could get away with injecting twice weekly. But at 50 mg TC per week I think it's safest to inject at least every other day, e.g. 14-15 mg EOD.</p><p></p><p>If you're going to consider alternative methods for raising testosterone then in my opinion a testosterone nasal gel such as Natesto should be first on the list. It has the least impact on your other hormones. At a minimum conventional TRT may disrupt LH, FSH and GnRH. More than a dozen other hormones can also be affected. Some men will experience side effects from these changes.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 213653, member: 38109"] One of the perils of coming to the forums for advice is that you will get a lot of different recommendations and information, sometimes quite contradictory. The half-life of testosterone cypionate in standard formulations is actually closer to five days, and typically one waits at least four to five half-lives before trying to see what serum levels are doing. Overall effects certainly can take a lot longer: [URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188848/[/URL] A starting dose of 50 mg TC per week is low but not unreasonably so. It's an average of 5 mg of testosterone per day, which compares to the 6-7 mg averaged naturally by healthy young men. Personally I've averaged as little as 3.8 mg per day without feeling hypogonadal. The bigger problem is the injection frequency. With weekly injections there are often large variations in serum hormone levels, with peak levels two to three times trough levels. This is what makes a lower dose untenable; the last day or two of each injection cycle will most likely be spent at hypogonadal testosterone levels. The preferred solution is to inject more often. At larger doses you could get away with injecting twice weekly. But at 50 mg TC per week I think it's safest to inject at least every other day, e.g. 14-15 mg EOD. If you're going to consider alternative methods for raising testosterone then in my opinion a testosterone nasal gel such as Natesto should be first on the list. It has the least impact on your other hormones. At a minimum conventional TRT may disrupt LH, FSH and GnRH. More than a dozen other hormones can also be affected. Some men will experience side effects from these changes. [/QUOTE]
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New member - 33yo recently starting TRT
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