madman
Super Moderator
A very interesting read for anyone who wants to develop a better understanding of drug absorption from a parenteral oil depot.
Long read but very informative.
Spatial distribution of oil depots monitored in human muscle using MRI.
The shape and surface areas of oil depots after injection is often regarded as a sphere when in fact MRI reveals that there is a stretched shape of the oily depot formed in muscle.
Really cool to see the oil depot in muscle using MRI on pg.74/77
Figure 4.6: A schematic image of the muscle before and after injection. The diameter of the needle is 0.5 mm. It is assumed that the perimysium between fascicles is pierced by the injection needle. Consequently, as a result of the injection, the oil depot will spread across multiple fascicles and push aside the muscle fibres to form a bulk (continuous) phase.
Figure 4.5: The oil depot directly after injection from volunteer C was obtained via post-processing whereby every voxel was analyzed to the amount of voxel intensity. This 3D-picture contains every voxel that had a voxel intensity of ≥ 0.5, which was marked as fat-fraction.
Figure 4.8: Visualisation of the oil depot in volunteer C. The images show the depot at day 4 and 8. White arrows indicate the oil depot in tissue.
Figure 4.9: Different depot properties using 0.3, 0.5 and 0.7 as cut-off voxel intensity value for fat fraction labelling. Data was obtained from volunteer C at day 8.
Pharmacokinetic profiles of benzyl alcohol and its metabolites benzoic acid and hippuric acid and how it affects the absorption of nandrolone decanoate.
Benzyl alcohol (BOH) is a commonly used excipient in oil depots in concentrations ranging from 1.5-10% v/v and is used as a
*solubility enhancer
*oil viscosity reducer
*local anesthetic
Long read but very informative.
Spatial distribution of oil depots monitored in human muscle using MRI.
The shape and surface areas of oil depots after injection is often regarded as a sphere when in fact MRI reveals that there is a stretched shape of the oily depot formed in muscle.
Really cool to see the oil depot in muscle using MRI on pg.74/77
Figure 4.6: A schematic image of the muscle before and after injection. The diameter of the needle is 0.5 mm. It is assumed that the perimysium between fascicles is pierced by the injection needle. Consequently, as a result of the injection, the oil depot will spread across multiple fascicles and push aside the muscle fibres to form a bulk (continuous) phase.
Figure 4.5: The oil depot directly after injection from volunteer C was obtained via post-processing whereby every voxel was analyzed to the amount of voxel intensity. This 3D-picture contains every voxel that had a voxel intensity of ≥ 0.5, which was marked as fat-fraction.
Figure 4.8: Visualisation of the oil depot in volunteer C. The images show the depot at day 4 and 8. White arrows indicate the oil depot in tissue.
Figure 4.9: Different depot properties using 0.3, 0.5 and 0.7 as cut-off voxel intensity value for fat fraction labelling. Data was obtained from volunteer C at day 8.
Pharmacokinetic profiles of benzyl alcohol and its metabolites benzoic acid and hippuric acid and how it affects the absorption of nandrolone decanoate.
Benzyl alcohol (BOH) is a commonly used excipient in oil depots in concentrations ranging from 1.5-10% v/v and is used as a
*solubility enhancer
*oil viscosity reducer
*local anesthetic
