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So, Doc consult has come and gone and I'm feeling good about moving forward.

Because my testes responded to a bump in LH from my last blood work, the doctor feels a restart trial with Clomid is the best first step. I'm also being prescribed an AI as a preventative measure to ward off any increase in estrogen, which he felt was already a little high relative to my total T. Trial will be for 30 days, then a taper, and then we'll see if it "holds." If not, a maintenance dose of Clomid or possibly TRT could be indicated.

For my adrenals, he suggested DHEA and pregnenolone for support.

I'm aware some men have reported a bump in test but no subjective benefit (more muscle mass, libido, energy, etc.) while on Clomid. In another thread here, someone linked to a Doctor Crisler message that said a bump in SHBG might be to blame, and that free T will need to be watched. I agree with this, and providing both free/total T are raised and estrogen is under control, I don't see why I wouldn't experience similar results to exogenous testosterone.

As Chris mentioned--will it hold? Dunno. Maybe I'll fall off after, maybe not. But I feel it's a valid and conservative approach, and one I'm happy to try.

<blockquote data-quote="Gizmo12" data-source="post: 12005" data-attributes="member: 2275">So, Doc consult has come and gone and I&#039;m feeling good about moving forward.Because my testes responded to a bump in LH from my last blood work, the doctor feels a restart trial with Clomid is the best first step. I&#039;m also being prescribed an AI as a preventative measure to ward off any increase in estrogen, which he felt was already a little high relative to my total T. Trial will be for 30 days, then a taper, and then we&#039;ll see if it &quot;holds.&quot; If not, a maintenance dose of Clomid or possibly TRT could be indicated.For my adrenals, he suggested DHEA and pregnenolone for support. I&#039;m aware some men have reported a bump in test but no subjective benefit (more muscle mass, libido, energy, etc.) while on Clomid. In another thread here, someone linked to a Doctor Crisler message that said a bump in SHBG might be to blame, and that free T will need to be watched. I agree with this, and providing both free/total T are raised and estrogen is under control, I don&#039;t see why I wouldn&#039;t experience similar results to exogenous testosterone. As Chris mentioned--will it hold? Dunno. Maybe I&#039;ll fall off after, maybe not. But I feel it&#039;s a valid and conservative approach, and one I&#039;m happy to try.</blockquote>

[QUOTE="Gizmo12, post: 12005, member: 2275"] So, Doc consult has come and gone and I'm feeling good about moving forward. Because my testes responded to a bump in LH from my last blood work, the doctor feels a restart trial with Clomid is the best first step. I'm also being prescribed an AI as a preventative measure to ward off any increase in estrogen, which he felt was already a little high relative to my total T. Trial will be for 30 days, then a taper, and then we'll see if it "holds." If not, a maintenance dose of Clomid or possibly TRT could be indicated. For my adrenals, he suggested DHEA and pregnenolone for support. I'm aware some men have reported a bump in test but no subjective benefit (more muscle mass, libido, energy, etc.) while on Clomid. In another thread here, someone linked to a Doctor Crisler message that said a bump in SHBG might be to blame, and that free T will need to be watched. I agree with this, and providing both free/total T are raised and estrogen is under control, I don't see why I wouldn't experience similar results to exogenous testosterone. As Chris mentioned--will it hold? Dunno. Maybe I'll fall off after, maybe not. But I feel it's a valid and conservative approach, and one I'm happy to try. [/QUOTE]

Verification

TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038