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*T is not only a hormone but also a prohormone with the ability to be converted into two biologically active hormones: DHT and estradiol. Both of them play important physiological roles, including bone metabolism, sexual functioning, and supporting male skin and body hair characteristics. Hence, the use of compounds (steroid and non-steroid) unsuitable for aromatization and/or 5α-reduction may not completely correct the hypogonadal state and its associated symptoms.