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My two cents...I think you're going about it the right way. Even if you are unable to find or fix a root cause, you can be at peace with having tried, and things you do fix will be farther upstream which is likely to be a good thing. Chris Masterjohn is one of the most insightful resources you will find. If, for example, you grew up drinking flouridated water, that could account for thyroid issues and may or may not be fixable. You may also want to look into chelation therapy now that is is relatively cheap.