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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
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<blockquote data-quote="madman" data-source="post: 204914" data-attributes="member: 13851"><p>When was blood work done?</p><p></p><p>Need to post reference ranges/assays used.</p><p></p><p>Testing should be done in a fasted state between 7-10 am as we want to test at peak.</p><p></p><p>During the 24hr circadian rhythm of a healthy young male testosterone levels will start to increase around 3-4 am reaching a peak between 6-8 am and by 11-12 pm will start to decline late afternoon/early evening reaching a trough between 6-8 pm.</p><p></p><p>Fluctuations from peak--->trough would be around 20-25%</p><p></p><p>Natural T levels follow a diurnal 24 hr circadian rhythm and will start to rise gradually around 3 am reaching peak levels around 8 am</p><p></p><p>Natural endogenous testosterone secretion is pulsatile and diurnal.</p><p></p><p>Keep in mind that dysfunction (thyroid/adrenals) can mimic symptoms of low-t.</p><p></p><p>Massive weight gain can hammer down T.</p><p></p><p>Was your SHBG tested as it will have a significant impact on TT/FT?</p><p></p><p>Even then although you tested TT your FT was most likely tested using an inaccurate assay.</p><p></p><p>The only way to know where your FT level truly sits is to have it tested using the most accurate assays such as the gold standard Equilibrium Dialysis or Ultrafiltration (next best).</p><p></p><p>When it comes to testing hormones it is critical to use accurate assays TT/estradiol/DHT (LC/MS-MS) and FT (ED or UF).</p><p></p><p>Although TT is important to know FT is what truly matters as it is the active unbound fraction of testosterone responsible for the positive effects.</p><p></p><p>As I stated previously where your SHBG sits will have a significant impact on TT/FT.</p><p></p><p>With a TT 490 ng/dL your FT would most likely be in the lower end normal/low depending on your SHBG.</p><p></p><p>Again the only way to know would be to have it tested using the most accurate assays.</p></blockquote><p></p>
[QUOTE="madman, post: 204914, member: 13851"] When was blood work done? Need to post reference ranges/assays used. Testing should be done in a fasted state between 7-10 am as we want to test at peak. During the 24hr circadian rhythm of a healthy young male testosterone levels will start to increase around 3-4 am reaching a peak between 6-8 am and by 11-12 pm will start to decline late afternoon/early evening reaching a trough between 6-8 pm. Fluctuations from peak--->trough would be around 20-25% Natural T levels follow a diurnal 24 hr circadian rhythm and will start to rise gradually around 3 am reaching peak levels around 8 am Natural endogenous testosterone secretion is pulsatile and diurnal. Keep in mind that dysfunction (thyroid/adrenals) can mimic symptoms of low-t. Massive weight gain can hammer down T. Was your SHBG tested as it will have a significant impact on TT/FT? Even then although you tested TT your FT was most likely tested using an inaccurate assay. The only way to know where your FT level truly sits is to have it tested using the most accurate assays such as the gold standard Equilibrium Dialysis or Ultrafiltration (next best). When it comes to testing hormones it is critical to use accurate assays TT/estradiol/DHT (LC/MS-MS) and FT (ED or UF). Although TT is important to know FT is what truly matters as it is the active unbound fraction of testosterone responsible for the positive effects. As I stated previously where your SHBG sits will have a significant impact on TT/FT. With a TT 490 ng/dL your FT would most likely be in the lower end normal/low depending on your SHBG. Again the only way to know would be to have it tested using the most accurate assays. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
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