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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Need for Thyroid Supplementation while on TRT.....
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<blockquote data-quote="Anonymon" data-source="post: 223060" data-attributes="member: 42608"><p>Getting my thyroid right was probably more useful to me than test, and I’ve done various things over the years with highly divergent results. Mostly wanted it for gut issues as nothing else helped or budged it as I seem to have actual injuries down there. Still figuring that out. Harder when you have lower cortisol like I do.</p><p></p><p>I did 1 grain of NDT for a while. Felt a little more emotional while adjusting to it, which in my case I found was from the T4 in it, not the T3. T4 actually has a higher affinity for transport proteins that cross the blood brain barrier, so I mentally feel thyroid effects more from things with T4 than T3, and T3 alone will tend to make me go a little numb, likely from it suppressing T4 since I can fix it within a day or so by just taking T4. Responded well to test and HCG on NDT.</p><p></p><p>After NDT I was off thyroid for a while, then tried slow release T3. Made my hair great but it shed rapidly and never really grew back to what it was. Sleep was worse. At the same test and HCG dose, my total T dropped and free T almost doubled and my E2 proportionally went up as well. SHBG unchanged. Also experienced complete erectile dysfunction from not being able to feel it down there. Cialis and all else did nothing since I couldn’t feel anything down there. Coming off fixed it in short order. Tried an AI and that didn’t help at all. Tried 25 and 35mcg, things being worse in a dose dependent manner. Also felt super dehydrated and achey when drinking plain water.</p><p></p><p>Off that, I tried levothyroxine (T4) with another protocol. That had my emotions super high and my dick working great. Just 75mcg. Free T and E2 were still higher than they had been on NDT. Taking Ashwagandha also makes me very readily convert unbound T4 into T3 and had my T3 pretty high (high 4’s). Felt kind of bad when eating. Stopping Ash stopped that in short order. Hair shed a lot.</p><p></p><p>Tried T3 after that (liothyronine) in 2 15mcg pills spread out after that. Fixed my gut but broke my dick. Hair didn’t shed this time. Splitting up the dose into many mini hits further segmented from that in 25/4mcg doses had my dick working decently. T3 on its own though had me very lethargic. Memory was worse. No motivation. Very low dopamine. Free T and E2 still higher. Last test was weird but almost all of my T was free. SHBG unchanged. Glycogen retention shit no matter what I do. Reading up on it and talking to people, T3 in unbound form has different affinities for different cells than it naturally would since T4 is a transport mechanism, so T3 more affects your muscle cells and heart where as T4 for me had me feeling warmer and such.</p><p></p><p>Experimented with straight T4 and some T3 hits after that and that’s what I do now. Still figuring that out. I have trouble retaining water in general where I’d want it. T4 is very diuretic and more salt on it literally makes my fingers crack and at times my face bleed. T3 in smaller hits throughout the day seems necessary for me to keep my gut in order and in general T3 is the only thing that really helped that more than anything. Eating some things before that was debilitating at times.</p><p></p><p>I’m using my blood tests regarding hydration and my gut and dick status there as a guide for where to let it land. T4 typically makes me feel like a super hero if I have some potassium with it.</p><p></p><p>If anyone wants an easy way to up T4 T3 conversion, Ashwagandha’s got a lot of backing behind it and that’s what it did for me based on blood tests, at least when on thyroid meds in unbound form like levothyroxine. Lowers cortisol too, both of which are why I had to drop Ash. I originally left NDT because of a shortage and I got switched to something else I didn’t react well to and have generally stayed off it since then because I can’t rely on getting it or it not being recalled. Weirdest thing for me on those meds is definitely my free T and E2 jumping up with total T going down and SHBG remaining the same. Last test had my total T at 460 and 300ish of it was free. Didn’t change my test dose or anything else. Doc said maybe my free T went up to balance out the increased E2 conversion which thyroid can verifiably increase, but it’s all been really weird.</p><p></p><p>Next experiment once my current thyroid protocol sets in is trying to lower my test dose and see what happens. Was on 12iu’s a day and 720iu’s of HCG 3x a week. Going to drop test to 8iu’s and see where my total and free T lands. Kind of scary considering my last blood test at that dose had a 460 total T with almost all of it being free, but I’d like to see what happens as in theory if my free T is so much higher I could get by with less, and I’d like to retain less water in my face.</p></blockquote><p></p>
[QUOTE="Anonymon, post: 223060, member: 42608"] Getting my thyroid right was probably more useful to me than test, and I’ve done various things over the years with highly divergent results. Mostly wanted it for gut issues as nothing else helped or budged it as I seem to have actual injuries down there. Still figuring that out. Harder when you have lower cortisol like I do. I did 1 grain of NDT for a while. Felt a little more emotional while adjusting to it, which in my case I found was from the T4 in it, not the T3. T4 actually has a higher affinity for transport proteins that cross the blood brain barrier, so I mentally feel thyroid effects more from things with T4 than T3, and T3 alone will tend to make me go a little numb, likely from it suppressing T4 since I can fix it within a day or so by just taking T4. Responded well to test and HCG on NDT. After NDT I was off thyroid for a while, then tried slow release T3. Made my hair great but it shed rapidly and never really grew back to what it was. Sleep was worse. At the same test and HCG dose, my total T dropped and free T almost doubled and my E2 proportionally went up as well. SHBG unchanged. Also experienced complete erectile dysfunction from not being able to feel it down there. Cialis and all else did nothing since I couldn’t feel anything down there. Coming off fixed it in short order. Tried an AI and that didn’t help at all. Tried 25 and 35mcg, things being worse in a dose dependent manner. Also felt super dehydrated and achey when drinking plain water. Off that, I tried levothyroxine (T4) with another protocol. That had my emotions super high and my dick working great. Just 75mcg. Free T and E2 were still higher than they had been on NDT. Taking Ashwagandha also makes me very readily convert unbound T4 into T3 and had my T3 pretty high (high 4’s). Felt kind of bad when eating. Stopping Ash stopped that in short order. Hair shed a lot. Tried T3 after that (liothyronine) in 2 15mcg pills spread out after that. Fixed my gut but broke my dick. Hair didn’t shed this time. Splitting up the dose into many mini hits further segmented from that in 25/4mcg doses had my dick working decently. T3 on its own though had me very lethargic. Memory was worse. No motivation. Very low dopamine. Free T and E2 still higher. Last test was weird but almost all of my T was free. SHBG unchanged. Glycogen retention shit no matter what I do. Reading up on it and talking to people, T3 in unbound form has different affinities for different cells than it naturally would since T4 is a transport mechanism, so T3 more affects your muscle cells and heart where as T4 for me had me feeling warmer and such. Experimented with straight T4 and some T3 hits after that and that’s what I do now. Still figuring that out. I have trouble retaining water in general where I’d want it. T4 is very diuretic and more salt on it literally makes my fingers crack and at times my face bleed. T3 in smaller hits throughout the day seems necessary for me to keep my gut in order and in general T3 is the only thing that really helped that more than anything. Eating some things before that was debilitating at times. I’m using my blood tests regarding hydration and my gut and dick status there as a guide for where to let it land. T4 typically makes me feel like a super hero if I have some potassium with it. If anyone wants an easy way to up T4 T3 conversion, Ashwagandha’s got a lot of backing behind it and that’s what it did for me based on blood tests, at least when on thyroid meds in unbound form like levothyroxine. Lowers cortisol too, both of which are why I had to drop Ash. I originally left NDT because of a shortage and I got switched to something else I didn’t react well to and have generally stayed off it since then because I can’t rely on getting it or it not being recalled. Weirdest thing for me on those meds is definitely my free T and E2 jumping up with total T going down and SHBG remaining the same. Last test had my total T at 460 and 300ish of it was free. Didn’t change my test dose or anything else. Doc said maybe my free T went up to balance out the increased E2 conversion which thyroid can verifiably increase, but it’s all been really weird. Next experiment once my current thyroid protocol sets in is trying to lower my test dose and see what happens. Was on 12iu’s a day and 720iu’s of HCG 3x a week. Going to drop test to 8iu’s and see where my total and free T lands. Kind of scary considering my last blood test at that dose had a 460 total T with almost all of it being free, but I’d like to see what happens as in theory if my free T is so much higher I could get by with less, and I’d like to retain less water in my face. [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Need for Thyroid Supplementation while on TRT.....
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