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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Natural T vs. Test Cyp.
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<blockquote data-quote="Cataceous" data-source="post: 223769" data-attributes="member: 38109"><p>This has been discussed in detail, but here's a quick recap from my perspective: First, testosterone cypionate is only 70% testosterone, so you need 70 mg of it to get the 49 mg of T per week. The testosterone in cypionate is bioidentical, meaning once it's loose your body can't tell it apart from natural T. Next, let's be generous and say that the full range of natural production is 3-9 mg per day. This corresponds to 30-90 mg T cypionate per week. Also, because testosterone cypionate does not provide normal diurnal variation in serum testosterone you have to increase the dose by ~20% to achieve the same peak levels. With this calculation you get a maximum dose of about 110 mg TC per week. This is in line with the Xyosted product, which is injectable testosterone enanthate. The only doses available are 50, 75 and 100 mg per week. Enanthate has only slightly more testosterone than cypionate. A final factor is the injection frequency. If you're injecting frequently—daily or EOD—then serum levels usually don't fluctuate too much. But if you're injecting once weekly then you can have large swings in serum testosterone, with peaks as much as 2.5-3 times larger than troughs. To put the troughs at minimum acceptable levels may require increasing the dose to over ~100 mg/week. However, this usually results in supraphysiological peaks.</p><p></p><p>This part is speculative: There are guys who insist they need supraphysiological dosing to feel good. If this is the case then perhaps the excessive dosing is compensating for the disruptions caused by TRT. For example, in some cases high doses may compensate for excessive estradiol, as eventually the aromatase enzyme starts to saturate and you can reduce your E2/T ratio. Of course there's the very real possibility of creating other imbalances, and the long-term safety is uncertain.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 223769, member: 38109"] This has been discussed in detail, but here's a quick recap from my perspective: First, testosterone cypionate is only 70% testosterone, so you need 70 mg of it to get the 49 mg of T per week. The testosterone in cypionate is bioidentical, meaning once it's loose your body can't tell it apart from natural T. Next, let's be generous and say that the full range of natural production is 3-9 mg per day. This corresponds to 30-90 mg T cypionate per week. Also, because testosterone cypionate does not provide normal diurnal variation in serum testosterone you have to increase the dose by ~20% to achieve the same peak levels. With this calculation you get a maximum dose of about 110 mg TC per week. This is in line with the Xyosted product, which is injectable testosterone enanthate. The only doses available are 50, 75 and 100 mg per week. Enanthate has only slightly more testosterone than cypionate. A final factor is the injection frequency. If you're injecting frequently—daily or EOD—then serum levels usually don't fluctuate too much. But if you're injecting once weekly then you can have large swings in serum testosterone, with peaks as much as 2.5-3 times larger than troughs. To put the troughs at minimum acceptable levels may require increasing the dose to over ~100 mg/week. However, this usually results in supraphysiological peaks. This part is speculative: There are guys who insist they need supraphysiological dosing to feel good. If this is the case then perhaps the excessive dosing is compensating for the disruptions caused by TRT. For example, in some cases high doses may compensate for excessive estradiol, as eventually the aromatase enzyme starts to saturate and you can reduce your E2/T ratio. Of course there's the very real possibility of creating other imbalances, and the long-term safety is uncertain. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Natural T vs. Test Cyp.
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