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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Natural 21M Very Low E2 Relative to T With Symptoms
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<blockquote data-quote="madman" data-source="post: 229011" data-attributes="member: 13851"><p>Highly doubtful creatine supplementation is going to have a significant impact on increasing DHT!</p><p></p><p>Deadset on that I see.</p><p></p><p>Did you read the full study?</p><p></p><p><strong>Three Weeks of Creatine Monohydrate Supplementation Affects Dihydrotestosterone to Testosterone Ratio in College-Aged Rugby Players (2009)</strong></p><p><em>van der Merwe, Johann MBChB; Brooks, Naomi E Ph.D.; Myburgh, Kathryn H PhD</em></p><p></p><p></p><p></p><p></p><p></p><p>Look up who Jose Antonio is!</p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/common-questions-and-misconceptions-about-creatine-supplementation.23513/#post-201817[/URL]</p><p></p><p><strong>Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show? (2021)</strong></p><p><em>Jose Antonio*, Darren G. Candow, Scott C. Forbes, Bruno Gualano, Andrew R. Jagim, Richard B. Kreider, Eric S. Rawson, Abbie E. Smith-Ryan, Trisha A. VanDusseldorp, Darryn S. Willoughby and Tim N. Ziegenfuss</em></p><p><em></em></p><p><em><strong>Does creatine cause hair loss/baldness? </strong></em></p><p><em><strong></strong></em></p><p><em><strong>The vast majority of speculation regarding the relationship between creatine supplementation and hair loss/ baldness stems from a </strong></em><strong><em><u>single study by van der Merwe et al. [61] where college-aged male rugby players who supplemented with creatine (25 g/day for 7 days, followed by 5 g/day thereafter for an additional 14 days) experienced an increase in serum dihydrotestosterone</u></em>.</strong></p><p></p><p><em><strong>(DHT) concentrations over time. Specifically, DHT increased by 56% after the seven-day loading period and remained 40% above baseline values after the 14-day maintenance period. These results were statistically significant compared to when the subjects consumed a placebo (50 g of glucose per day for 7 days, followed by 30 g/day for 14 days thereafter). <u>Given that changes in these hormones, particularly DHT, have been linked to some (but not all) occurrences of hair loss/baldness [62], the theory that creatine supplementation leads to hair loss/baldness gained some momentum and this potential link continues to be a common question/myth today</u>. <u>It is important to note that the results of van der Merwe et al. [61] have not been replicated and that intense resistance exercise itself can cause increases in these androgenic hormones</u>.</strong></em></p><p><em><strong></strong></em></p><p><em><strong>DHT is a metabolite of testosterone, formed when the enzyme 5-alpha-reductase converts free testosterone to DHT [63]. In males, DHT can bind to androgen receptors in susceptible hair follicles and cause them to shrink, ultimately leading to hair loss [64].</strong> <strong><u>However, in the van der Merwe et al. [61] study, no increase in total testosterone was found in the 16 males who completed the study</u>. <u>Free testosterone was not measured</u>. <u>Moreover, the increase in DHT and the DHT: testosterone ratio remained well within normal clinical limits</u>. <u>Furthermore, at baseline (prior to supplementation), DHT was 23% lower in the creatine group (0.98 nmol/L) compared to the placebo group (1.26 nmol/L)</u>. <u>Thus the small increase in DHT in the creatine group (+ 0.55 nmol/L after 7 days of supplementation and + 0.40 nmol/L after 21 days of supplementation), in combination with a small decrease in the placebo DHT response (-0.17 nmol/L after 7 days of supplementation and -0.20 nmol/L after 21 days of supplementation) explains the “statistically significant” increase in DHT noted by van der Merwe et al</u>. [61].</strong> <strong><u>While it is possible that creatine supplementation upregulated 5- alpha-reductase activity in these males (potentially leading to increased formation of DHT), no study has reported hair loss/baldness in humans</u>.</strong></em></p><p></p><p><strong><em>To date, 12 other studies have investigated the effects of creatine supplementation (i.e. doses ranging from 3-25 g/ day for 6 days to 12 weeks) on testosterone. <u>Two studies reported small, physiologically insignificant increases in total testosterone after six and seven days of supplementation [65, 66], while the remaining ten studies reported no change in testosterone concentrations</u>. <u>In five of these studies [67– 71], free testosterone, which the body uses to produce DHT, was also measured and no increases were found</u>.</em></strong></p><p><strong><em></em></strong></p><p><strong><em></em></strong></p><p><strong><em></em></strong></p><p><strong><em>*In summary, the current body of evidence does not indicate that creatine supplementation increases total testosterone, free testosterone, DHT, or causes hair loss/baldness.</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 229011, member: 13851"] Highly doubtful creatine supplementation is going to have a significant impact on increasing DHT! Deadset on that I see. Did you read the full study? [B]Three Weeks of Creatine Monohydrate Supplementation Affects Dihydrotestosterone to Testosterone Ratio in College-Aged Rugby Players (2009)[/B] [I]van der Merwe, Johann MBChB; Brooks, Naomi E Ph.D.; Myburgh, Kathryn H PhD[/I] Look up who Jose Antonio is! [URL unfurl="true"]https://www.excelmale.com/forum/threads/common-questions-and-misconceptions-about-creatine-supplementation.23513/#post-201817[/URL] [B]Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show? (2021)[/B] [I]Jose Antonio*, Darren G. Candow, Scott C. Forbes, Bruno Gualano, Andrew R. Jagim, Richard B. Kreider, Eric S. Rawson, Abbie E. Smith-Ryan, Trisha A. VanDusseldorp, Darryn S. Willoughby and Tim N. Ziegenfuss [B]Does creatine cause hair loss/baldness? The vast majority of speculation regarding the relationship between creatine supplementation and hair loss/ baldness stems from a [/B][/I][B][I][U]single study by van der Merwe et al. [61] where college-aged male rugby players who supplemented with creatine (25 g/day for 7 days, followed by 5 g/day thereafter for an additional 14 days) experienced an increase in serum dihydrotestosterone[/U][/I].[/B] [I][B](DHT) concentrations over time. Specifically, DHT increased by 56% after the seven-day loading period and remained 40% above baseline values after the 14-day maintenance period. These results were statistically significant compared to when the subjects consumed a placebo (50 g of glucose per day for 7 days, followed by 30 g/day for 14 days thereafter). [U]Given that changes in these hormones, particularly DHT, have been linked to some (but not all) occurrences of hair loss/baldness [62], the theory that creatine supplementation leads to hair loss/baldness gained some momentum and this potential link continues to be a common question/myth today[/U]. [U]It is important to note that the results of van der Merwe et al. [61] have not been replicated and that intense resistance exercise itself can cause increases in these androgenic hormones[/U]. DHT is a metabolite of testosterone, formed when the enzyme 5-alpha-reductase converts free testosterone to DHT [63]. In males, DHT can bind to androgen receptors in susceptible hair follicles and cause them to shrink, ultimately leading to hair loss [64].[/B] [B][U]However, in the van der Merwe et al. [61] study, no increase in total testosterone was found in the 16 males who completed the study[/U]. [U]Free testosterone was not measured[/U]. [U]Moreover, the increase in DHT and the DHT: testosterone ratio remained well within normal clinical limits[/U]. [U]Furthermore, at baseline (prior to supplementation), DHT was 23% lower in the creatine group (0.98 nmol/L) compared to the placebo group (1.26 nmol/L)[/U]. [U]Thus the small increase in DHT in the creatine group (+ 0.55 nmol/L after 7 days of supplementation and + 0.40 nmol/L after 21 days of supplementation), in combination with a small decrease in the placebo DHT response (-0.17 nmol/L after 7 days of supplementation and -0.20 nmol/L after 21 days of supplementation) explains the “statistically significant” increase in DHT noted by van der Merwe et al[/U]. [61].[/B] [B][U]While it is possible that creatine supplementation upregulated 5- alpha-reductase activity in these males (potentially leading to increased formation of DHT), no study has reported hair loss/baldness in humans[/U].[/B][/I] [B][I]To date, 12 other studies have investigated the effects of creatine supplementation (i.e. doses ranging from 3-25 g/ day for 6 days to 12 weeks) on testosterone. [U]Two studies reported small, physiologically insignificant increases in total testosterone after six and seven days of supplementation [65, 66], while the remaining ten studies reported no change in testosterone concentrations[/U]. [U]In five of these studies [67– 71], free testosterone, which the body uses to produce DHT, was also measured and no increases were found[/U]. *In summary, the current body of evidence does not indicate that creatine supplementation increases total testosterone, free testosterone, DHT, or causes hair loss/baldness.[/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Natural 21M Very Low E2 Relative to T With Symptoms
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