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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Natesto: large shards UPDATE- batch is all bad.
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<blockquote data-quote="trax123" data-source="post: 277297" data-attributes="member: 46508"><p>Interesting that you have so many vials! I have only 1 out of 6 that was mostly clean - 1-2 visible crystals, this is the one I'm trial-using right now.</p><p></p><p>The 'gentleness' of Natesto in terms of its rapid half-life and relatively low dose I believe makes determining the dosing (on a physiology basis) even more difficult. Testing is also - as was mentioned above - highly inaccurate because of the pulsatile nature and the differential absorption through the nasal membranes for different people - it's very difficult to 'time' a blood test to catch the T peak as such.</p><p></p><p>1. I think a better experiment is to compare against Empower's nasal gel. Clearly this less sophisticated 30-compound mixture 'cream' formulation is very different and I guess might be more stable (though it may also be slower to absorb if I had to guess), BUT it might be a more accurate representation of the effects and efficiacy of pulsed low-dose nasal delivered T. i.e. the cruder formulary version might be superior to the fancier patented Natesto gel because Natesto's manufacturing/shelf stability is so poor/temperature fragile.</p><p></p><p>2. I may try Empower's formulation given I doubt I will have ANY hope of getting Acerus to do anything about this, let alone to pick up the phone.</p><p></p><p><em>3. While I LOVE the concept of a nasal gel - really smart - I'm also beginning to wonder if JATENZO might just be easier all around and actually more effective. It's becoming more appealing due to these Natesto manufacturing/quality issues which I don't see really getting resolved.</em></p><p><em></em></p><p><em>I have seen VERY FEW reports from people online about JATENZO. Other than the hypertension black box warning apparently it does increase HCT more than desirable in some people - almost certainly because of its longer half-life; the nasal gels don't do that at all. OTOH Jatenzo seems 'stronger' in terms of clinical response. </em></p><p></p><p>(My completely unsupported hypothesis is that PO TRT-related drugs like Jatenzo or Clomiphene/enclomiphene work faster (even faster than IM injections or gels) because the GI to bloodstream pathway - portal or lymphatic - is the 2nd fastest possible systemic route of admin (aside from IV of course) and more rapidly achieves saturation esp. at the doses easily achievable in pills. This isn't really apropos of anything but it's something I've noticed from reports.</p></blockquote><p></p>
[QUOTE="trax123, post: 277297, member: 46508"] Interesting that you have so many vials! I have only 1 out of 6 that was mostly clean - 1-2 visible crystals, this is the one I'm trial-using right now. The 'gentleness' of Natesto in terms of its rapid half-life and relatively low dose I believe makes determining the dosing (on a physiology basis) even more difficult. Testing is also - as was mentioned above - highly inaccurate because of the pulsatile nature and the differential absorption through the nasal membranes for different people - it's very difficult to 'time' a blood test to catch the T peak as such. 1. I think a better experiment is to compare against Empower's nasal gel. Clearly this less sophisticated 30-compound mixture 'cream' formulation is very different and I guess might be more stable (though it may also be slower to absorb if I had to guess), BUT it might be a more accurate representation of the effects and efficiacy of pulsed low-dose nasal delivered T. i.e. the cruder formulary version might be superior to the fancier patented Natesto gel because Natesto's manufacturing/shelf stability is so poor/temperature fragile. 2. I may try Empower's formulation given I doubt I will have ANY hope of getting Acerus to do anything about this, let alone to pick up the phone. [I]3. While I LOVE the concept of a nasal gel - really smart - I'm also beginning to wonder if JATENZO might just be easier all around and actually more effective. It's becoming more appealing due to these Natesto manufacturing/quality issues which I don't see really getting resolved. I have seen VERY FEW reports from people online about JATENZO. Other than the hypertension black box warning apparently it does increase HCT more than desirable in some people - almost certainly because of its longer half-life; the nasal gels don't do that at all. OTOH Jatenzo seems 'stronger' in terms of clinical response. [/I] (My completely unsupported hypothesis is that PO TRT-related drugs like Jatenzo or Clomiphene/enclomiphene work faster (even faster than IM injections or gels) because the GI to bloodstream pathway - portal or lymphatic - is the 2nd fastest possible systemic route of admin (aside from IV of course) and more rapidly achieves saturation esp. at the doses easily achievable in pills. This isn't really apropos of anything but it's something I've noticed from reports. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Natesto: large shards UPDATE- batch is all bad.
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