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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Natesto: large shards UPDATE- batch is all bad.
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<blockquote data-quote="trax123" data-source="post: 277257" data-attributes="member: 46508"><p>Hey - yes I had noticed you were a very active Natesto poster on here! </p><p></p><p>I've also noted though people DO report many instances of suspecting Natesto wasn't being dosed correctly or evenly? We also know Natesto did recall vials for this reason.</p><p></p><p>Finally, it's of course well known that IV solutions do crystallize, and warming them for dissolution is a well reported phenomenon.</p><p></p><p>That said, you obviously have had years of use, so that's quite interesting in itself. I don't believe the crystallization is normal since the gel only contains 3 components - the hormone, castor oil, and some glyceride substrates. So I MUST assume that the crystals represent Testosterone precipitating out of solution.</p><p></p><p>The pharmacist I showed this to concurred that he himself would probably not take such a drug believing it to have probably 'cooled down too much during storage' and that "wherever they are warehousing the Natesto they may be storing it in chilled rooms alongside other drugs or perhaps even mistakenly keeping it chilled believing that it requires it."</p><p></p><p>I do believe though that given the 3x a day use (meaning each vial is fully administered in 10 days), AND given the fact that effects can be difficult to detect on a dose-by-dose basis for some, obviously the drug IS being delivered somewhere over those 30 doses just probably very unevenly. I suspect this COULD explain a lot of the reported erratic responses to Natesto.</p><p></p><p>As Mr. Granger has noted above, he has experienced major spikes (explained by applying a full crystal of the hormone) on Natesto while other times experiencing nothing. This is consistent with the drug not being properly mixed.</p><p></p><p>I also note some that reported using Empower's Nasal gel (which is an entirely different formulation) reported that the Empower seemed to produce instant physiological responses / were clearly cognizant they had administered the drug. This would also make sense since perhaps Empower's formula keeps the hormone dissolved more readily.</p><p></p><p>I'm speculating of course, but I will say that Mr. Granger's experience as reported seems very supportive to me. Furthermore, I have experienced zero effects on Natesto after a week of dosings from crystallized gel. Yes of course it's possible I either am not responsive at all OR I need to keep using it for several weeks... but inevitably eventually I will extrude a crystal... and presumably have a response. I am exquisitely sensitive to clomiphene for instance and had physiological responses within a few hours of dosing it in the past during a trial.</p><p></p><p>All this said - I'd be very curious to know if ALL your vials over these years have been crystallized or not.</p></blockquote><p></p>
[QUOTE="trax123, post: 277257, member: 46508"] Hey - yes I had noticed you were a very active Natesto poster on here! I've also noted though people DO report many instances of suspecting Natesto wasn't being dosed correctly or evenly? We also know Natesto did recall vials for this reason. Finally, it's of course well known that IV solutions do crystallize, and warming them for dissolution is a well reported phenomenon. That said, you obviously have had years of use, so that's quite interesting in itself. I don't believe the crystallization is normal since the gel only contains 3 components - the hormone, castor oil, and some glyceride substrates. So I MUST assume that the crystals represent Testosterone precipitating out of solution. The pharmacist I showed this to concurred that he himself would probably not take such a drug believing it to have probably 'cooled down too much during storage' and that "wherever they are warehousing the Natesto they may be storing it in chilled rooms alongside other drugs or perhaps even mistakenly keeping it chilled believing that it requires it." I do believe though that given the 3x a day use (meaning each vial is fully administered in 10 days), AND given the fact that effects can be difficult to detect on a dose-by-dose basis for some, obviously the drug IS being delivered somewhere over those 30 doses just probably very unevenly. I suspect this COULD explain a lot of the reported erratic responses to Natesto. As Mr. Granger has noted above, he has experienced major spikes (explained by applying a full crystal of the hormone) on Natesto while other times experiencing nothing. This is consistent with the drug not being properly mixed. I also note some that reported using Empower's Nasal gel (which is an entirely different formulation) reported that the Empower seemed to produce instant physiological responses / were clearly cognizant they had administered the drug. This would also make sense since perhaps Empower's formula keeps the hormone dissolved more readily. I'm speculating of course, but I will say that Mr. Granger's experience as reported seems very supportive to me. Furthermore, I have experienced zero effects on Natesto after a week of dosings from crystallized gel. Yes of course it's possible I either am not responsive at all OR I need to keep using it for several weeks... but inevitably eventually I will extrude a crystal... and presumably have a response. I am exquisitely sensitive to clomiphene for instance and had physiological responses within a few hours of dosing it in the past during a trial. All this said - I'd be very curious to know if ALL your vials over these years have been crystallized or not. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Natesto: large shards UPDATE- batch is all bad.
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