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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Natesto: large shards UPDATE- batch is all bad.
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<blockquote data-quote="trax123" data-source="post: 277029" data-attributes="member: 46508"><p>Wanted to update on this. I obtained a second batch of Natesto (Dec 2025 expiry) and indeed the vials ALSO have inclusion crystals in them (thank you Zalemax for posting that photo above seemingly confirming that these inclusions are NOT present in all vials and do not seem to be a normal consequence of manufacturing). </p><p></p><p>This is definitely very disappointing and I'm shocked Acerus apparently has Inventorying/stocking AND manufacturing QC problems such as these. </p><p></p><p>Not really sure what to do yet - physician has offered the compounded "Empower" nasal gel version though this is also a bit of a letdown given all the studies were performed on Natesto AND there seems to be no reason they shouldn't be able to manufacture a simple gel without so much trouble. </p><p></p><p>I may try the new gel even though I see the crystals in there... </p><p></p><p>*I suspect this may not be widely reported because 1) the total number of Natesto users is not that high and 2) I think clinically after let's say 1 week of 3x daily use of COURSE the drug eventually goes in since the crystals are extruded. So of course the patient eventually responds to the drug. Given the effects are delayed, function differently in people based on their sensitivity and drug acclimation, etc. the patient reported effects probably are not being correlated with the simple fact that instead what is happening is the drug is being heavily underdosed and overdosed in that same time period.</p><p></p><p>So patients aren't noticing basically they're doing placebos for 2 days then a crystal of T then placebos etc. Not only that but Natesto's MOA actually involves a cyclical type of applique like this so even more reason for many to not notice it. </p><p></p><p>On the other hand this is obviously improper dosing (and totally unacceptable for an FDA approved drug) AND will likely NOT reproduce the drug's clinical findings given I assume they were performed with properly dispensed Natesto.</p></blockquote><p></p>
[QUOTE="trax123, post: 277029, member: 46508"] Wanted to update on this. I obtained a second batch of Natesto (Dec 2025 expiry) and indeed the vials ALSO have inclusion crystals in them (thank you Zalemax for posting that photo above seemingly confirming that these inclusions are NOT present in all vials and do not seem to be a normal consequence of manufacturing). This is definitely very disappointing and I'm shocked Acerus apparently has Inventorying/stocking AND manufacturing QC problems such as these. Not really sure what to do yet - physician has offered the compounded "Empower" nasal gel version though this is also a bit of a letdown given all the studies were performed on Natesto AND there seems to be no reason they shouldn't be able to manufacture a simple gel without so much trouble. I may try the new gel even though I see the crystals in there... *I suspect this may not be widely reported because 1) the total number of Natesto users is not that high and 2) I think clinically after let's say 1 week of 3x daily use of COURSE the drug eventually goes in since the crystals are extruded. So of course the patient eventually responds to the drug. Given the effects are delayed, function differently in people based on their sensitivity and drug acclimation, etc. the patient reported effects probably are not being correlated with the simple fact that instead what is happening is the drug is being heavily underdosed and overdosed in that same time period. So patients aren't noticing basically they're doing placebos for 2 days then a crystal of T then placebos etc. Not only that but Natesto's MOA actually involves a cyclical type of applique like this so even more reason for many to not notice it. On the other hand this is obviously improper dosing (and totally unacceptable for an FDA approved drug) AND will likely NOT reproduce the drug's clinical findings given I assume they were performed with properly dispensed Natesto. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Natesto: large shards UPDATE- batch is all bad.
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