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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Natesto: large shards UPDATE- batch is all bad.
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<blockquote data-quote="trax123" data-source="post: 276263" data-attributes="member: 46508"><p>Update on this: two pharmacies and a physician noted they have never had any patients complain about crystallization with Natesto gel (they note its possible of course though). Acerus is basically unreachable/a shell company it seems they don't communicate with anyone (surprising the drug gets made at all!). They felt it would likely have been a temperature storage issue rather than a manufacturing one.</p><p></p><p>Physician also noted that the nasal form can be slow to take effect - even with good absorption - despite being bioidentical; apparently because the dose is very low and the spike - while significant - has a very short half-life (which is ofc a key operating 'feature' of Natesto). It can take several weeks in most patients to note any changes because of the very rapid dropoff in the level (this makes sense - clomiphene for instance has a much longer half-life effect because it doesn't merely add a hormone but manipulates the HPG feedback mechanism which doesn't pulse but acts continuously). All of Natesto's published studies were noted at 90 days I believe, though they did comment that within 30 days some patients reported various clinical responses.</p><p></p><p>In either case - these people all seem to believe that the crystallization, while real, may not have any actual clinical effect. </p><p></p><p>I've requested a new batch in either case, and I will close the loop on my experience with that.</p></blockquote><p></p>
[QUOTE="trax123, post: 276263, member: 46508"] Update on this: two pharmacies and a physician noted they have never had any patients complain about crystallization with Natesto gel (they note its possible of course though). Acerus is basically unreachable/a shell company it seems they don't communicate with anyone (surprising the drug gets made at all!). They felt it would likely have been a temperature storage issue rather than a manufacturing one. Physician also noted that the nasal form can be slow to take effect - even with good absorption - despite being bioidentical; apparently because the dose is very low and the spike - while significant - has a very short half-life (which is ofc a key operating 'feature' of Natesto). It can take several weeks in most patients to note any changes because of the very rapid dropoff in the level (this makes sense - clomiphene for instance has a much longer half-life effect because it doesn't merely add a hormone but manipulates the HPG feedback mechanism which doesn't pulse but acts continuously). All of Natesto's published studies were noted at 90 days I believe, though they did comment that within 30 days some patients reported various clinical responses. In either case - these people all seem to believe that the crystallization, while real, may not have any actual clinical effect. I've requested a new batch in either case, and I will close the loop on my experience with that. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Natesto: large shards UPDATE- batch is all bad.
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