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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Natesto: large shards UPDATE- batch is all bad.
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<blockquote data-quote="trax123" data-source="post: 275954" data-attributes="member: 46508"><p>Surprised you're the ONLY poster who mentioned this. 100% new to TRT and after 3 days realized Natesto was completely ineffective, zero physical or psychological changes. </p><p></p><p>At first I thought maybe it was from poor absorption - used a cotton swab to better layer the gel in the nares, no effect. Then I thought perhaps it's because I have a history of nasal inflammation/allergies. But while that COULD reduce efficacy, it wouldn't go to ZERO. Testosterone is a powerful hormone and while skin transmission of course varies heavily between users, it's unlikely nothing would get through - clinical trials clearly showed significant serum spikes from the gel. </p><p></p><p>I also one time took a single pill - just one - of clomiphene - and had an almost instantaneous response. Different MoA but suggests I'm sensitive to increases in serum T in general. </p><p></p><p>SO I started looking for the next most likely issue - perhaps the drug is just misformulated or something is defective, and I FOUND YOUR POST here. </p><p></p><p>I checked the vial and indeed there are crystals identical to your photograph! Same expiry June 2025, and the vials I have are all the same lot number.</p><p></p><p>While it SHOCKS me that they could put out a product that is so obviously defective, and while I'm not 100% sure here (e.g. PERHAPS skin aborption really IS that bad, the dose it too low... etc.), your explanation DOES seem very plausible to me.</p><p></p><p>If the drug is precipitating out of the gel solution then basically the gel is inert castor oil and no hormone is being delivered, which explains why I have had zero effects after several applications; the actual hormone is all coagulated into crystals. Pumping/sucking out one of the crystals would result in a potentially massive overdose! That's QUITE dangerous sounding at worst, and at best leaves you with a completely nonfunctional therapy.</p><p></p><p>I'm going to inquire with pharmacy as well as Acerus (though they almost went bankrupt and are now owned by a private equity company so while I think they did great scientific work, it's not the best situation in terms of a supplier).</p><p></p><p>Thank you for posting this as I have no familiarity with gels, etc., and I never would have considered it was precipitating like that.</p></blockquote><p></p>
[QUOTE="trax123, post: 275954, member: 46508"] Surprised you're the ONLY poster who mentioned this. 100% new to TRT and after 3 days realized Natesto was completely ineffective, zero physical or psychological changes. At first I thought maybe it was from poor absorption - used a cotton swab to better layer the gel in the nares, no effect. Then I thought perhaps it's because I have a history of nasal inflammation/allergies. But while that COULD reduce efficacy, it wouldn't go to ZERO. Testosterone is a powerful hormone and while skin transmission of course varies heavily between users, it's unlikely nothing would get through - clinical trials clearly showed significant serum spikes from the gel. I also one time took a single pill - just one - of clomiphene - and had an almost instantaneous response. Different MoA but suggests I'm sensitive to increases in serum T in general. SO I started looking for the next most likely issue - perhaps the drug is just misformulated or something is defective, and I FOUND YOUR POST here. I checked the vial and indeed there are crystals identical to your photograph! Same expiry June 2025, and the vials I have are all the same lot number. While it SHOCKS me that they could put out a product that is so obviously defective, and while I'm not 100% sure here (e.g. PERHAPS skin aborption really IS that bad, the dose it too low... etc.), your explanation DOES seem very plausible to me. If the drug is precipitating out of the gel solution then basically the gel is inert castor oil and no hormone is being delivered, which explains why I have had zero effects after several applications; the actual hormone is all coagulated into crystals. Pumping/sucking out one of the crystals would result in a potentially massive overdose! That's QUITE dangerous sounding at worst, and at best leaves you with a completely nonfunctional therapy. I'm going to inquire with pharmacy as well as Acerus (though they almost went bankrupt and are now owned by a private equity company so while I think they did great scientific work, it's not the best situation in terms of a supplier). Thank you for posting this as I have no familiarity with gels, etc., and I never would have considered it was precipitating like that. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Natesto: large shards UPDATE- batch is all bad.
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