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With Natesto, testosterone should be measured about an hour after taking a dose. Your number is a bit lower than average, but free testosterone is still ok. It could be interesting to experiment with a SERM, but I would start with lower doses of clomiphene, e.g. 12.5 mg 3x a week. If it's estrogenic action you're lacking then clomiphene will boost it. But if you don't need it or like the results then you'll be stuck with it for a while, because the zuclomiphene isomer has a very long half-life, sometimes given as a month or so. Your SHBG is on the low side, so no harm in getting a boost there; contrary to popular belief, rising SHBG does not lower free testosterone in normal circumstances.

If you want to try the experiment without the boost in estrogenic activity then you would need to find a source for enclomiphene. Rumor has it that Empower is still selling it. If not then it may not be possible to obtain a pharmaceutical grade product.

<blockquote data-quote="Cataceous" data-source="post: 251075" data-attributes="member: 38109">With Natesto, testosterone should be measured about an hour after taking a dose. Your number is a bit lower than average, but free testosterone is still ok. It could be interesting to experiment with a SERM, but I would start with lower doses of clomiphene, e.g. 12.5 mg 3x a week. If it&#039;s estrogenic action you&#039;re lacking then clomiphene will boost it. But if you don&#039;t need it or like the results then you&#039;ll be stuck with it for a while, because the zuclomiphene isomer has a very long half-life, sometimes given as a month or so. Your SHBG is on the low side, so no harm in getting a boost there; contrary to popular belief, rising SHBG does not lower free testosterone in normal circumstances.If you want to try the experiment without the boost in estrogenic activity then you would need to find a source for enclomiphene. Rumor has it that Empower is still selling it. If not then it may not be possible to obtain a pharmaceutical grade product.</blockquote>

[QUOTE="Cataceous, post: 251075, member: 38109"] With Natesto, testosterone should be measured about an hour after taking a dose. Your number is a bit lower than average, but free testosterone is still ok. It could be interesting to experiment with a SERM, but I would start with lower doses of clomiphene, e.g. 12.5 mg 3x a week. If it's estrogenic action you're lacking then clomiphene will boost it. But if you don't need it or like the results then you'll be stuck with it for a while, because the zuclomiphene isomer has a very long half-life, sometimes given as a month or so. Your SHBG is on the low side, so no harm in getting a boost there; contrary to popular belief, rising SHBG does not lower free testosterone in normal circumstances. If you want to try the experiment without the boost in estrogenic activity then you would need to find a source for enclomiphene. Rumor has it that Empower is still selling it. If not then it may not be possible to obtain a pharmaceutical grade product. [/QUOTE]

Verification

TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038