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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Natesto Application
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<blockquote data-quote="madman" data-source="post: 269100" data-attributes="member: 13851"><p>You are wasting your time here.</p><p></p><p>Natesto is meant to/needs to be applied intranasally in order to reap the benefits of the PK.</p><p></p><p>In and out of your system quickly due to the half-life of unesterified T.</p><p></p><p>Dosed 2-3 times daily which results in a short-lived peak with long trough times between doses.</p><p></p><p>The main reason one would choose Natesto over any other form of exogenous T is that it will cause the least suppression of the hpta out of all the T formulations.</p><p></p><p>Minimal <a href="https://www.excelmale.com/forum/threads/clomid-for-testicular-shrinkage.20049/" target="_blank">testicular shrinkage</a> and maintaining fertility without having to add in an ancillary like hCG to boot.</p><p></p><p>Minimal impact when it comes to side effects (cosmetic/blood markers), especially elevated hematocrit.</p><p></p><p>If you are dead set on transdermal application then you are far better off using a compounded T cream or big pharma gel.</p><p></p><p>Look over Figure 1 (PK) as this is the magic behind Natesto's minimal suppression of the hpta.</p><p></p><p>The key point here is a short-lived peak with long trough times between doses.</p><p></p><p></p><p></p><p><strong>12.3. Pharmacokinetics</strong></p><p><strong></strong></p><p><strong>Absorption</strong></p><p></p><p><em>Natesto delivers physiologic amounts of testosterone, producing circulating concentrations that approximate normal testosterone concentrations (i.e., 300 to 1,050 ng/dL) seen in healthy men. <strong>The maximum concentration for Natesto is achieved within approximately 40 minutes of administration and has a half-life ranging from 10 to 100 minutes.</strong></em></p><p><em><strong></strong></em></p><p><em><strong>Figure 1 summarizes the <u>pharmacokinetic profiles of total testosterone</u> in patients completing 90 days of Natesto treatment <u>administered as 33 mg of testosterone daily</u> (<u>11 mg three times daily</u>).</strong></em></p><p></p><p>[ATTACH=full]38955[/ATTACH]</p><p>[ATTACH=full]38956[/ATTACH]</p><p></p><p></p><p></p><p></p><p>[ATTACH=full]38950[/ATTACH]</p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p><em><strong>*Patients should be instructed to report any nasal symptoms or signs to their healthcare professional</strong></em><strong><em>. In that circumstance, healthcare professionals should determine whether further evaluation (e.g., otorhinolaryngology consultation) or <u>discontinuation of Natesto is appropriate</u>.</em></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>5. WARNINGS AND PRECAUTIONS</strong></p><p><strong></strong></p><p><strong>5.1 Nasal Adverse Reactions and Limited Long-Term Information on Nasal Safety </strong></p><p></p><p><em><strong>Nasal adverse reactions, including nasopharyngitis, rhinorrhea, epistaxis, nasal discomfort, and nasal scabbing, were reported in the clinical trial experience with Natesto. <u>All nasal adverse reactions except one</u> (a single case of upper respiratory infection) <u>were reported as mild or moderate in severity; however, long-term clinical trial data on nasal safety is available in a limited number of subjects</u> [see Adverse Reactions (6.2)]. <u>Patients should be instructed to report any nasal symptoms or signs to their healthcare professional</u>. <u>In that circumstance, healthcare professionals should determine whether further evaluation (e.g., otorhinolaryngology consultation) or discontinuation of Natesto is appropriate</u>.</strong></em></p><p><em><strong></strong></em></p><p><em><strong>[ATTACH=full]38951[/ATTACH]</strong></em></p><p><em><strong>[ATTACH=full]38952[/ATTACH]</strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong>[ATTACH=full]38953[/ATTACH]</strong></em></p><p><em><strong>[ATTACH=full]38954[/ATTACH]</strong></em></p></blockquote><p></p>
[QUOTE="madman, post: 269100, member: 13851"] You are wasting your time here. Natesto is meant to/needs to be applied intranasally in order to reap the benefits of the PK. In and out of your system quickly due to the half-life of unesterified T. Dosed 2-3 times daily which results in a short-lived peak with long trough times between doses. The main reason one would choose Natesto over any other form of exogenous T is that it will cause the least suppression of the hpta out of all the T formulations. Minimal [URL='https://www.excelmale.com/forum/threads/clomid-for-testicular-shrinkage.20049/']testicular shrinkage[/URL] and maintaining fertility without having to add in an ancillary like hCG to boot. Minimal impact when it comes to side effects (cosmetic/blood markers), especially elevated hematocrit. If you are dead set on transdermal application then you are far better off using a compounded T cream or big pharma gel. Look over Figure 1 (PK) as this is the magic behind Natesto's minimal suppression of the hpta. The key point here is a short-lived peak with long trough times between doses. [B]12.3. Pharmacokinetics Absorption[/B] [I]Natesto delivers physiologic amounts of testosterone, producing circulating concentrations that approximate normal testosterone concentrations (i.e., 300 to 1,050 ng/dL) seen in healthy men. [B]The maximum concentration for Natesto is achieved within approximately 40 minutes of administration and has a half-life ranging from 10 to 100 minutes. Figure 1 summarizes the [U]pharmacokinetic profiles of total testosterone[/U] in patients completing 90 days of Natesto treatment [U]administered as 33 mg of testosterone daily[/U] ([U]11 mg three times daily[/U]).[/B][/I] [ATTACH type="full" alt="1699484208820.png"]38955[/ATTACH] [ATTACH type="full" alt="1699484253461.png"]38956[/ATTACH] [ATTACH type="full" alt="Screenshot (30504).png"]38950[/ATTACH] [I][B]*Patients should be instructed to report any nasal symptoms or signs to their healthcare professional[/B][/I][B][I]. In that circumstance, healthcare professionals should determine whether further evaluation (e.g., otorhinolaryngology consultation) or [U]discontinuation of Natesto is appropriate[/U].[/I] 5. WARNINGS AND PRECAUTIONS 5.1 Nasal Adverse Reactions and Limited Long-Term Information on Nasal Safety [/B] [I][B]Nasal adverse reactions, including nasopharyngitis, rhinorrhea, epistaxis, nasal discomfort, and nasal scabbing, were reported in the clinical trial experience with Natesto. [U]All nasal adverse reactions except one[/U] (a single case of upper respiratory infection) [U]were reported as mild or moderate in severity; however, long-term clinical trial data on nasal safety is available in a limited number of subjects[/U] [see Adverse Reactions (6.2)]. [U]Patients should be instructed to report any nasal symptoms or signs to their healthcare professional[/U]. [U]In that circumstance, healthcare professionals should determine whether further evaluation (e.g., otorhinolaryngology consultation) or discontinuation of Natesto is appropriate[/U]. [ATTACH type="full" alt="Screenshot (30509).png"]38951[/ATTACH] [ATTACH type="full" alt="Screenshot (30510).png"]38952[/ATTACH] [ATTACH type="full" alt="Screenshot (30511).png"]38953[/ATTACH] [ATTACH type="full" alt="Screenshot (30512).png"]38954[/ATTACH][/B][/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Natesto Application
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