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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Nandrolone - What to expect - Hb/HCT, HDL, Muscle?
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<blockquote data-quote="madman" data-source="post: 219384" data-attributes="member: 13851"><p>Regarding cypionate vs enanthate.</p><p></p><p><strong><em>post #2</em></strong></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/testosterone-enanthate-and-testosterone-cypionate-half-lives-data.23467/#post-201453[/URL]</p><p></p><p></p><p></p><p></p><p>NDs half-life roughly 6-7 days.</p><p></p><p>Again the gains in muscle size/strength would be minimal when using <100mg/week let alone you are not going to notice a significant difference using 100 mg/week.</p><p></p><p>If anything 200 mg/week is where you would see the anabolic potential shine.</p><p></p><p>ND is considered one of the milder AAS when it comes to sides.</p><p></p><p>If your goal is to add some size and you plan on a short-term stint (12 weeks) then I would jump on 200 mg/week to maximize the returns.</p><p></p><p>Only time will tell as to what degree such dose drives up your RBCs/hemoglobin/hematocrit and even then it will be temporary.</p><p></p><p>Can even give 150 mg/week a go if you feel more comfortable.</p><p></p><p>Forget the mumbo jumbo about needing protein every 2 hrs.</p><p></p><p>As long as you are meeting your daily protein requirements 1 gram protein/lb of LBM spread evenly throughout the day and you are taking in enough calories (carbs/fats) then you should be good to go.</p><p></p><p>If increased mass/strength gains are your goal then consuming complex carbs is critical especially if you are naturally lean or have a hard time putting on weight.</p><p></p><p>Forget the keto/carnivore unless you have poor insulin sensitivity and carry a lot of body fat/put on weight easily. Regardless of your body type, it is much easier to pack on quality mass when consuming complex carbs.</p><p></p><p>Muscle will always be bigger, fuller, and harder when glycogen stores are topped up!</p><p></p><p>Strength/recovery is also better.</p><p></p><p></p><p></p><p></p><h4>[URL unfurl="true"]https://www.ncbi.nlm.nih.gov/books/NBK279000/[/URL]</h4><h4><strong>Injectable Testosterone</strong></h4><p><em>The most widely used testosterone formulation for many decades has been intramuscular injection of testosterone esters (<a href="https://www.ncbi.nlm.nih.gov/books/NBK279000/figure/andro-phys-pharm-abs.F5/?report=objectonly" target="_blank">figure 5</a>), formed by 17β-esterification of testosterone with fatty acids of various aliphatic and/or aromatic chain lengths, injected in a vegetable oil vehicle (<a href="https://www.ncbi.nlm.nih.gov/books/NBK279000/#" target="_blank">653</a>). This depot product relies on retarded release of the testosterone ester from the oil vehicle injection depot because esters undergo rapid hydrolysis by ubiquitous esterases to liberate free testosterone into the circulation. <strong>The pharmacokinetics and pharmacodynamics of androgen esters is therefore primarily determined by ester side-chain length, volume of oil vehicle, and site of injection via hydrophobic physicochemical partitioning of the androgen ester between the hydrophobic oil vehicle and the aqueous extracellular fluid (<a href="https://www.ncbi.nlm.nih.gov/books/NBK279000/#" target="_blank">654</a>).</strong></em></p><p><em></em></p><p><em>The short 3-carbon aliphatic ester side-chain of testosterone propionate gives the product a brief duration of action requiring injections of 25 to 50 mg at 1-2 day intervals for effective testosterone replacement therapy.<strong> In contrast, the 7-carbon side-chain of testosterone enanthate has a longer duration of action </strong>so that it is used at doses of 200 to 250 mg per 10 to 14 days for androgen replacement therapy in hypogonadal men (<a href="https://www.ncbi.nlm.nih.gov/books/NBK279000/#" target="_blank">655</a>-<a href="https://www.ncbi.nlm.nih.gov/books/NBK279000/#" target="_blank">657</a>) and has been for decades the most widely used form of testosterone used in replacement therapy.<strong> Other testosterone esters (cypionate, cyclohexane carboxylate) have simillar pharmacokinetics making them pharmacologically equivalent to testosterone enanthate (<a href="https://www.ncbi.nlm.nih.gov/books/NBK279000/#" target="_blank">658</a>).</strong> Similarly, mixtures of short- and longer acting testosterone esters also have essentially the same pharmacokinetics of the longest ester.</em></p><h4></h4><h4><strong>TESTOSTERONE ESTERS</strong>[ATTACH=full]20277[/ATTACH]</h4><h3>FIGURE 5.</h3><p><em>Schematic overview of the pharmacology of testosterone esters. <strong>Testosterone is esterified through the 17 β hydroxyl group with fatty acid esters of different aliphatic or other chain length which is a biologically inactive pro-drug. </strong>The esterified testosterone in an oil vehicle is injected deeply into a muscle forming a local drug depot from which the testosterone ester is released at a slow rate determined by its physico-chemical partitioning according to the testosterone ester’s hydrophobicity. Once the testosterone ester exits the depot and enters the extracellular fluids, it is rapidly hydrolyzed by ubiquitous non-specific esterases thereby releasing the testosterone into the general circulation.</em></p><p></p><p></p><p></p><p></p><p><strong><em>*The pharmacokinetics and pharmacodynamics of androgen esters are therefore primarily determined by ester side-chain length, the volume of oil vehicle, and site of injection via hydrophobic physicochemical partitioning of the androgen ester between the hydrophobic oil vehicle and the aqueous extracellular fluid (<a href="https://www.ncbi.nlm.nih.gov/books/NBK279000/#" target="_blank">654</a>).</em></strong></p><p></p><p></p><p><em><strong>*7-carbon aliphatic ester side-chain (TE)</strong></em></p><p><strong></strong></p><p><strong><em>*8-carbon aliphatic ester side-chain (TC)</em></strong></p><p><strong><em></em></strong></p><p><strong><em>*10-carbon aliphatic ester side-chain (ND)</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 219384, member: 13851"] Regarding cypionate vs enanthate. [B][I]post #2[/I][/B] [URL unfurl="true"]https://www.excelmale.com/forum/threads/testosterone-enanthate-and-testosterone-cypionate-half-lives-data.23467/#post-201453[/URL] NDs half-life roughly 6-7 days. Again the gains in muscle size/strength would be minimal when using <100mg/week let alone you are not going to notice a significant difference using 100 mg/week. If anything 200 mg/week is where you would see the anabolic potential shine. ND is considered one of the milder AAS when it comes to sides. If your goal is to add some size and you plan on a short-term stint (12 weeks) then I would jump on 200 mg/week to maximize the returns. Only time will tell as to what degree such dose drives up your RBCs/hemoglobin/hematocrit and even then it will be temporary. Can even give 150 mg/week a go if you feel more comfortable. Forget the mumbo jumbo about needing protein every 2 hrs. As long as you are meeting your daily protein requirements 1 gram protein/lb of LBM spread evenly throughout the day and you are taking in enough calories (carbs/fats) then you should be good to go. If increased mass/strength gains are your goal then consuming complex carbs is critical especially if you are naturally lean or have a hard time putting on weight. Forget the keto/carnivore unless you have poor insulin sensitivity and carry a lot of body fat/put on weight easily. Regardless of your body type, it is much easier to pack on quality mass when consuming complex carbs. Muscle will always be bigger, fuller, and harder when glycogen stores are topped up! Strength/recovery is also better. [HEADING=3][URL unfurl="true"]https://www.ncbi.nlm.nih.gov/books/NBK279000/[/URL][/HEADING] [HEADING=3][B]Injectable Testosterone[/B][/HEADING] [I]The most widely used testosterone formulation for many decades has been intramuscular injection of testosterone esters ([URL='https://www.ncbi.nlm.nih.gov/books/NBK279000/figure/andro-phys-pharm-abs.F5/?report=objectonly']figure 5[/URL]), formed by 17β-esterification of testosterone with fatty acids of various aliphatic and/or aromatic chain lengths, injected in a vegetable oil vehicle ([URL='https://www.ncbi.nlm.nih.gov/books/NBK279000/#']653[/URL]). This depot product relies on retarded release of the testosterone ester from the oil vehicle injection depot because esters undergo rapid hydrolysis by ubiquitous esterases to liberate free testosterone into the circulation. [B]The pharmacokinetics and pharmacodynamics of androgen esters is therefore primarily determined by ester side-chain length, volume of oil vehicle, and site of injection via hydrophobic physicochemical partitioning of the androgen ester between the hydrophobic oil vehicle and the aqueous extracellular fluid ([URL='https://www.ncbi.nlm.nih.gov/books/NBK279000/#']654[/URL]).[/B] The short 3-carbon aliphatic ester side-chain of testosterone propionate gives the product a brief duration of action requiring injections of 25 to 50 mg at 1-2 day intervals for effective testosterone replacement therapy.[B] In contrast, the 7-carbon side-chain of testosterone enanthate has a longer duration of action [/B]so that it is used at doses of 200 to 250 mg per 10 to 14 days for androgen replacement therapy in hypogonadal men ([URL='https://www.ncbi.nlm.nih.gov/books/NBK279000/#']655[/URL]-[URL='https://www.ncbi.nlm.nih.gov/books/NBK279000/#']657[/URL]) and has been for decades the most widely used form of testosterone used in replacement therapy.[B] Other testosterone esters (cypionate, cyclohexane carboxylate) have simillar pharmacokinetics making them pharmacologically equivalent to testosterone enanthate ([URL='https://www.ncbi.nlm.nih.gov/books/NBK279000/#']658[/URL]).[/B] Similarly, mixtures of short- and longer acting testosterone esters also have essentially the same pharmacokinetics of the longest ester.[/I] [HEADING=3][/HEADING] [HEADING=3][B]TESTOSTERONE ESTERS[/B][ATTACH type="full"]20277[/ATTACH][/HEADING] [HEADING=2]FIGURE 5.[/HEADING] [I]Schematic overview of the pharmacology of testosterone esters. [B]Testosterone is esterified through the 17 β hydroxyl group with fatty acid esters of different aliphatic or other chain length which is a biologically inactive pro-drug. [/B]The esterified testosterone in an oil vehicle is injected deeply into a muscle forming a local drug depot from which the testosterone ester is released at a slow rate determined by its physico-chemical partitioning according to the testosterone ester’s hydrophobicity. Once the testosterone ester exits the depot and enters the extracellular fluids, it is rapidly hydrolyzed by ubiquitous non-specific esterases thereby releasing the testosterone into the general circulation.[/I] [B][I]*The pharmacokinetics and pharmacodynamics of androgen esters are therefore primarily determined by ester side-chain length, the volume of oil vehicle, and site of injection via hydrophobic physicochemical partitioning of the androgen ester between the hydrophobic oil vehicle and the aqueous extracellular fluid ([URL='https://www.ncbi.nlm.nih.gov/books/NBK279000/#']654[/URL]).[/I][/B] [I][B]*7-carbon aliphatic ester side-chain (TE)[/B][/I] [B] [I]*8-carbon aliphatic ester side-chain (TC) *10-carbon aliphatic ester side-chain (ND)[/I][/B] [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Nandrolone - What to expect - Hb/HCT, HDL, Muscle?
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