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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Nandrolone for Mood | Feeling much Better..
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<blockquote data-quote="Fortunate" data-source="post: 222682" data-attributes="member: 42264"><p>Dammit - you guys are posting too much science too quickly! I gotta read the rest of the page, but the TGM study is interesting. Makes me wonder if androgen mediated vasodilatation is the primary mechanism for headaches I experience with even modest doses of testosterone. There is a lot of debate about the migraine mechanism (vascular vs. neurologic pathways, vs. vasculature of neurons themselves), but I have noted with confidence that vasodilatation (or, at least vascular instability) causes me headaches. That's probably why verapamil and beta blockers have been pretty helpful for me - they may stabilize neurovasculature. Triptans (miracle for me) supposedly work by neurovasculature constriction. </p><p></p><p>I also suspect that androgens' affect on the cardiovascular system is complex, as they may impact: cardiac stroke volume (stimulate myocytes), rhythm (impact on SA or AV node) peripheral vascular resistance (via smooth muscle receptors on vasculature and/or nitric oxide influence), blood pressure (vascular resistance and hematocrit), etc. I have more reading to do, but I wonder if the CV influence is mediated specifically by androgen receptors in the CV system or if androgen ligands happen to look similar to catecholamines? Maybe genetics play a role, with variability of androgen/adrenergic receptors, making some more likely to notice cardiac side effects?</p><p></p><p>Just thinking out loud. This is a good discussion.</p></blockquote><p></p>
[QUOTE="Fortunate, post: 222682, member: 42264"] Dammit - you guys are posting too much science too quickly! I gotta read the rest of the page, but the TGM study is interesting. Makes me wonder if androgen mediated vasodilatation is the primary mechanism for headaches I experience with even modest doses of testosterone. There is a lot of debate about the migraine mechanism (vascular vs. neurologic pathways, vs. vasculature of neurons themselves), but I have noted with confidence that vasodilatation (or, at least vascular instability) causes me headaches. That's probably why verapamil and beta blockers have been pretty helpful for me - they may stabilize neurovasculature. Triptans (miracle for me) supposedly work by neurovasculature constriction. I also suspect that androgens' affect on the cardiovascular system is complex, as they may impact: cardiac stroke volume (stimulate myocytes), rhythm (impact on SA or AV node) peripheral vascular resistance (via smooth muscle receptors on vasculature and/or nitric oxide influence), blood pressure (vascular resistance and hematocrit), etc. I have more reading to do, but I wonder if the CV influence is mediated specifically by androgen receptors in the CV system or if androgen ligands happen to look similar to catecholamines? Maybe genetics play a role, with variability of androgen/adrenergic receptors, making some more likely to notice cardiac side effects? Just thinking out loud. This is a good discussion. [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Nandrolone for Mood | Feeling much Better..
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