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Not sure what to make of this. It would have been interesting to see a control group of biological men with similar T levels. Also, the Hyperlipid blog had a post some years back about FMD being a far-from-precise measurement. Finally, as I've written about before regarding Nandrolone, there are benefits that may cancel out any negatives. In my case I am able to maintain a significantly higher level of activity on TRT+ that I can without it ( I used to come off for 3 months or so a year so I have a fair amount of experience experimenting.) The higher capacity (due primarily to better recovery capacity) let's me do more of heart-healthy things like sprinting and other conditioning work that would be a recipe for overtraining otherwise, so I hesitate to put too much weight on any one variable.